Coldwell Craig M, Bender William S
Department of Psychiatry, Dartmouth Medical School, Center for Evalative and Clinical Sciences, Dartmouth College, Hanover, NH, USA.
Am J Psychiatry. 2007 Mar;164(3):393-9. doi: 10.1176/ajp.2007.164.3.393.
The purpose of this study was to assess the effectiveness of assertive community treatment in the rehabilitation of homeless persons with severe mental illness using a meta-analysis.
A structured literature search identified studies for review. Inclusion criteria were the use of an assertive community treatment-based rehabilitation treatment in an experimental or quasi-experimental model, exclusive treatment of homeless subjects, and follow-up of housing and psychiatric outcomes. Two reviewers independently abstracted data on methodology and outcomes from included studies. The authors calculated effect differences, summary effects and confidence intervals (CIs) for housing, and hospitalization and symptom severity outcomes.
Of the 52 abstracts identified, 10 (19%) met inclusion criteria. Of these, six were randomized controlled trials, and four were observational studies, totaling 5,775 subjects. In randomized trials, assertive community treatment subjects demonstrated a 37% (95% CI=18%-55%) greater reduction in homelessness and a 26% (95% CI=7%-44%) greater improvement in psychiatric symptom severity compared with standard case management treatments. Hospitalization outcomes were not significantly different between the two groups. In observational studies, assertive community treatment subjects experienced a 104% (95% CI=67%-141%) further reduction in homelessness and a 62% (95% CI=0%-124%) further reduction in symptom severity compared with pretreatment comparison subjects.
Assertive community treatment offers significant advantages over standard case management models in reducing homelessness and symptom severity in homeless persons with severe mental illness.
本研究旨在通过荟萃分析评估积极社区治疗对患有严重精神疾病的无家可归者康复的有效性。
通过结构化文献检索确定纳入综述的研究。纳入标准为在实验或准实验模型中使用基于积极社区治疗的康复治疗、仅治疗无家可归者以及对住房和精神科结局进行随访。两名评审员独立提取纳入研究中关于方法和结局的数据。作者计算了住房、住院和症状严重程度结局的效应差异、汇总效应和置信区间(CI)。
在检索到的52篇摘要中,10篇(19%)符合纳入标准。其中,6篇为随机对照试验,4篇为观察性研究,共有5775名受试者。在随机试验中,与标准病例管理治疗相比,接受积极社区治疗的受试者无家可归情况减少了37%(95%CI=18%-55%),精神症状严重程度改善了26%(95%CI=7%-44%)。两组的住院结局无显著差异。在观察性研究中,与治疗前的对照受试者相比,接受积极社区治疗的受试者无家可归情况进一步减少了104%(95%CI=67%-141%),症状严重程度进一步降低了62%(95%CI=0%-124%)。
在减少患有严重精神疾病的无家可归者的无家可归情况和症状严重程度方面,积极社区治疗比标准病例管理模式具有显著优势。