Gould Neda F, Holmes M Kathleen, Fantie Bryan D, Luckenbaugh David A, Pine Daniel S, Gould Todd D, Burgess Neil, Manji Husseini K, Zarate Carlos A
Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, NIMH, Mark O. Hatfield Clinical Research Center, 10 Center Dr., Bethesda, MD 20892, USA.
Am J Psychiatry. 2007 Mar;164(3):516-9. doi: 10.1176/ajp.2007.164.3.516.
Findings on spatial memory in depression have been inconsistent. A navigation task based on virtual reality may provide a more sensitive and consistent measure of the hippocampal-related spatial memory deficits associated with depression.
Performance on a novel virtual reality navigation task and a traditional measure of spatial memory was assessed in 30 depressed patients (unipolar and bipolar) and 19 normal comparison subjects.
Depressed patients performed significantly worse than comparison subjects on the virtual reality task, as assessed by the number of locations found in the virtual town. Between-group differences were not detected on the traditional measure. The navigation task showed high test-retest reliability.
Depressed patients performed worse than healthy subjects on a novel spatial memory task. Virtual reality navigation may provide a consistent, sensitive measure of cognitive deficits in patients with affective disorders, representing a mechanism to study a putative endophenotype for hippocampal function.
关于抑郁症患者空间记忆的研究结果并不一致。基于虚拟现实的导航任务可能会为与抑郁症相关的海马体相关空间记忆缺陷提供更敏感和一致的测量方法。
对30名抑郁症患者（单相和双相）和19名正常对照受试者进行了一项新型虚拟现实导航任务和传统空间记忆测量的表现评估。
通过在虚拟城镇中找到的地点数量评估，抑郁症患者在虚拟现实任务中的表现明显比对照受试者差。在传统测量中未检测到组间差异。导航任务显示出高重测信度。
在一项新型空间记忆任务中，抑郁症患者的表现比健康受试者差。虚拟现实导航可能为情感障碍患者的认知缺陷提供一种一致、敏感的测量方法，代表了一种研究海马体功能假定内表型的机制。
