Herbert C A, Eckery D C, Trigg T E, Cooper D W
School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia.
Biol Reprod. 2007 Jun;76(6):1054-61. doi: 10.1095/biolreprod.107.059915. Epub 2007 Feb 28.
The present study evaluated the effects of chronic GnRH agonist (deslorelin) treatment on sexual maturation in the male tammar wallaby. Slow-release deslorelin or placebo implants were administered to male pouch young (n = 10/group) when they were between 180 and 200 days old, to determine if disruption of the pituitary-testicular axis during development altered the timing of sexual maturation or had long-term effects on adult reproductive function. Deslorelin treatment caused retardation of testicular growth and reduced the serum FSH and testosterone concentrations between 12 and 24 mo of age. Maturation of the hypothalamic-pituitary-testicular axis was also delayed in treated animals at 13 and 19 mo of age. Despite these alterations in the pattern and timing of neuroendocrine development, sexual maturation was not permanently blocked in these animals and deslorelin-treated animals reached sexual maturity at the same age as treated animals, as evidenced by a fully functional pituitary-testicular axis and proven fertility at 25 mo of age. The ability of the treated animals to reach puberty at the same time as control animals, despite delayed maturation of the hypothalamic-pituitary-testicular axis, suggests that puberty in the male tammar wallaby is additionally regulated by other, gonadotropin-independent factors.
本研究评估了慢性促性腺激素释放激素激动剂（地洛瑞林）治疗对雄性帚尾袋貂性成熟的影响。当雄性育儿袋幼兽在180至200日龄时，对其植入缓释地洛瑞林或安慰剂（每组n = 10），以确定发育过程中垂体 - 睾丸轴的破坏是否会改变性成熟的时间，或对成年生殖功能产生长期影响。地洛瑞林治疗导致睾丸生长迟缓，并降低了12至24月龄时的血清促卵泡激素（FSH）和睾酮浓度。在13和19月龄时，接受治疗的动物下丘脑 - 垂体 - 睾丸轴的成熟也延迟了。尽管神经内分泌发育的模式和时间发生了这些改变，但这些动物的性成熟并未被永久阻断，地洛瑞林治疗的动物与对照动物在相同年龄达到性成熟，25月龄时垂体 - 睾丸轴功能完全正常且已证实具有生育能力即可证明。尽管下丘脑 - 垂体 - 睾丸轴成熟延迟，但接受治疗的动物与对照动物同时达到青春期的能力表明，雄性帚尾袋貂的青春期还受其他与促性腺激素无关的因素调节。
