Zhang Hui, Kang Ning, Qiu Feng, Qu Ge-Xia, Yao Xin-Sheng
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, P.R.China.
Chem Pharm Bull (Tokyo). 2007 Mar;55(3):451-4. doi: 10.1248/cpb.55.451.
Further study on the microbial transformation of curcumol (1) by Cunninghamella blakesleana (AS3.970) led to the isolation of four novel metabolites. Their structures were elucidated as 3beta-hydroxy curcumol (2), 12-hydroxy curcumol (3), 1alpha-hydroxy-10beta,14-epoxy curcumol (4) and (2S,4S,5S,7S)-10-hydroxymethyl-7-isopropyl-2-methoxy-4-methyl-1-oxaspiro[4,6]undec-10-en-8-one (5) on the basis of spectral methods. All of them were characterized as new compounds.
