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棘皮动物神经节苷脂的神经发生活性及其构效关系。

Neuritogenic activity of gangliosides from echinoderms and their structure-activity relationship.

作者信息

Kaneko Masafumi, Yamada Koji, Miyamoto Tomofumi, Inagaki Masanori, Higuchi Ryuichi

机构信息

Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi, Fukuoka, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2007 Mar;55(3):462-3. doi: 10.1248/cpb.55.462.

DOI:10.1248/cpb.55.462
PMID:17329892
Abstract

The effects of the gangliosides isolated from echinoderms on the neuritogenesis of a rat pheochromocytoma cell line (PC-12 cells) in the presence of nerve growth factor were investigated. The results show that they displayed neuritogenic activity. Based on the observed results, a structure-activity relationship has been established.

摘要

研究了从棘皮动物中分离出的神经节苷脂在神经生长因子存在的情况下对大鼠嗜铬细胞瘤细胞系（PC - 12细胞）神经突生长的影响。结果表明它们具有神经突生长活性。基于观察结果，建立了构效关系。

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