Tinari Antonella, Garofalo Tina, Sorice Maurizio, Esposti Mauro Degli, Malorni Walter
Department of Technology and Health, Istituto Superiore di Sanita', Rome, Italy.
Autophagy. 2007 May-Jun;3(3):282-4. doi: 10.4161/auto.3924. Epub 2007 May 31.
Mitoptosis was described as a sort of mitochondrial death program. It could be associated with both necrosis and apoptosis, although degenerating mitochondria are also found in autophagic vacuoles. It was demonstrated that several molecules might contribute to the remodeling and rearrangement of mitochondrial membranes, leading to mitochondria rupture and disruption. Here, we hypothesize that, at least in T cells, two main pathways of mitoptosis can occur: an inner membrane mitoptosis (IMM), in which only the internal matrix and cristae are lost while the external mitochondrial envelope remains unaltered, and an outer membrane mitoptosis (OMM) where only swollen internal cristae are detected as remnants. We suggest that the study of these processes could provide useful insights not only to the field of cell death but also to the study of the pathogenic mechanisms of mitochondria-associated human diseases.
线粒体凋亡被描述为一种线粒体死亡程序。它可能与坏死和凋亡都有关联，尽管在自噬泡中也发现了退化的线粒体。已证明几种分子可能有助于线粒体膜的重塑和重排，导致线粒体破裂和瓦解。在此，我们假设，至少在T细胞中，可能会发生两种主要的线粒体凋亡途径：内膜线粒体凋亡（IMM），其中只有内部基质和嵴消失，而外部线粒体膜保持不变；外膜线粒体凋亡（OMM），其中仅检测到肿胀的内部嵴作为残余物。我们认为，对这些过程的研究不仅可以为细胞死亡领域提供有用的见解，也有助于研究线粒体相关人类疾病的致病机制。
