Palmer C N A, Doney A S F, Ismail T, Lee S P, Murrie I, Macgregor D F, Mukhopadhyay S
Biomedical Research Centre, Ninewells Hospital, University of Dundee, Scotland, UK.
Clin Pharmacol Ther. 2007 May;81(5):713-8. doi: 10.1038/sj.clpt.6100119. Epub 2007 Feb 28.
The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates inflammation and may play a role in asthma. Using mouthwash-derived DNA and clinical interviews and measurements, we investigated the association of previously characterized single-nucleotide polymorphisms in the PPARG gene (Pro12Ala, C1431T, and C-681G) with asthma exacerbations in patients aged 3-22 years (n=569). The common homozygous haplotype combination of the Pro12 and C1431 alleles was associated with increased risk for asthma exacerbations (ProC, odds ratio (OR) 1.87, 95% confidence interval 1.25-2.79; P=0.002). The ProC genotype was associated with increased school absences (OR 1.82, 95% confidence interval 1.21-2.76; P=0.004) and hospital admissions (OR 2.32, 95% confidence interval 1.18-4.58; P=0.015) over the preceding 6 months. The population-attributable risk of this genotype was 33%. Common genetic variation at the PPARG locus may play an important role in modulating the long-term control of asthma in children and young adults.
过氧化物酶体增殖物激活受体γ（PPARγ）调节炎症，可能在哮喘中发挥作用。我们使用漱口水来源的DNA、临床访谈和测量方法，研究了PPARG基因中先前已鉴定的单核苷酸多态性（Pro12Ala、C1431T和C - 681G）与3至22岁患者（n = 569）哮喘加重之间的关联。Pro12和C1431等位基因的常见纯合单倍型组合与哮喘加重风险增加相关（ProC，比值比（OR）1.87，95%置信区间1.25 - 2.79；P = 0.002）。在过去6个月中，ProC基因型与缺课增加（OR 1.82，95%置信区间1.21 - 2.76；P = 0.004）和住院率增加（OR 2.32，95%置信区间1.18 - 4.58；P = 0.015）相关。该基因型的人群归因风险为33%。PPARG基因座的常见基因变异可能在调节儿童和年轻人哮喘的长期控制中起重要作用。
