抗雌激素对大鼠乳腺肿瘤和人乳腺癌细胞溶质体外特异性结合（3H）雌二醇的影响。
Influence of anti-oestrogens on the specific binding in vitro of (3H)oestradiol by cytosol of rat mammary tumours and human breast carcinomata.
作者信息
Powell-Jones W, Jenner D A, Blamey R W, Davies P, Griffiths K
出版信息
Biochem J. 1975 Jul;150(1):71-5. doi: 10.1042/bj1500071.
Abstract
The anti-oestrogenic potential of two nitrogen-mustard-containing compounds, I.C.I. 79792 and I.C.I. 85966, was studied. I.C.I. 85966 usually did not decrease specific binding of [3H]oestradiol by breast-tumour cytoplasmic proteins. I.C.I. 79792 decreased specific [3H]oestradiol binding, but not to the same extent as similar concentrations of I.C.I. 46474, diethylstilboestrol or dibutyldihydrostilboestrol.
摘要
对两种含氮芥化合物ICI 79792和ICI 85966的抗雌激素潜力进行了研究。ICI 85966通常不会降低[3H]雌二醇与乳腺肿瘤细胞质蛋白的特异性结合。ICI 79792降低了[3H]雌二醇的特异性结合，但降低程度不如相同浓度的ICI 46474、己烯雌酚或二丁基二氢己烯雌酚。
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