一种用于晚期乳腺癌的新型抗雌激素药物。ICI46474的早期临床评估。
A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI46474.
作者信息
Cole M P, Jones C T, Todd I D
出版信息
Br J Cancer. 1971 Jun;25(2):270-5. doi: 10.1038/bjc.1971.33.
Abstract
An introductory clinical trial of the anti-oestrogenic agent IC146474 in late or recurrent carcinoma of the breast is described.Forty-six patients have been treated, of whom 10 have shown a good response. This is of the same order as that seen with oestrogens and androgens.The particular advantage of this drug is the low incidence of troublesome side effects.
摘要
本文描述了抗雌激素药物IC146474用于晚期或复发性乳腺癌的初步临床试验。46例患者接受了治疗，其中10例有良好反应。这与使用雌激素和雄激素时的情况相当。这种药物的特别优势在于不良副作用的发生率较低。
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A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI46474.一种用于晚期乳腺癌的新型抗雌激素药物。ICI46474的早期临床评估。
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本文引用的文献
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New synthetic agent for the induction of ovulation: preliminary trials in women.
Br Med J. 1971 Jan 16;1(5741):152-4. doi: 10.1136/bmj.1.5741.152.
2
Role of estrogens in ovulation: A study using the estrogen-antagonist, I.C.I. 46,474.
Endocrinology. 1970 Sep;87(3):542-51. doi: 10.1210/endo-87-3-542.
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