Solomon Daniel H, Stedman Margaret, Licari Andrea, Weinblatt Michael E, Maher Nancy, Shadick Nancy
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Arthritis Rheum. 2007 Mar 15;57(2):234-9. doi: 10.1002/art.22549.
With the growth in patient registries in rheumatic disease research, it is important to validate the collected information. We examined the convergent validity of self-reported medication use for rheumatoid arthritis (RA).
In the setting of the Brigham Rheumatoid Arthritis Sequential Study (BRASS), a large registry of patients with RA, we examined the agreement between patients' self-report of current and past RA medication use and information from medical records. For a sample of patients in BRASS, these 2 sources of information were compared using the kappa statistic as well as the percent agreement.
The 91 patients selected for assessment were typical of a prevalent RA cohort: >80% were women and the mean disease duration was 16 years. The agreement for current medication use was excellent, ranging from 0.71 for sulfasalazine to 0.96 for methotrexate. However, for past medication use agreement was lower, ranging from 0.13 for methotrexate to 0.74 for aurothioglucose. The weighted kappa for cumulative oral glucocorticoid dose was 0.67.
Self-report of current medication use and cumulative oral glucocorticoid dose appears to have moderate to excellent validity. However, self-report of past medication use may not be valid.
随着风湿病研究中患者登记数量的增加，验证所收集信息的有效性非常重要。我们检验了类风湿关节炎（RA）自我报告的用药情况的收敛效度。
在布莱根妇女医院类风湿关节炎序贯研究（BRASS）中，这是一个大型的RA患者登记库，我们检验了患者对当前和过去RA用药情况的自我报告与病历信息之间的一致性。对于BRASS中的一组患者样本，使用kappa统计量以及一致性百分比对这两种信息来源进行比较。
被选作评估的91例患者是典型的RA流行队列：超过80%为女性，平均病程为16年。当前用药情况的一致性很好，柳氮磺胺吡啶的一致性为0.71，甲氨蝶呤为0.96。然而，对于过去用药情况的一致性较低，甲氨蝶呤为0.13，金硫葡糖为0.74。累积口服糖皮质激素剂量的加权kappa值为0.67。
当前用药情况和累积口服糖皮质激素剂量的自我报告似乎具有中度至高度的效度。然而，过去用药情况的自我报告可能无效。
