[Expression of synaptophysin in experimental diffuse brain injury].

OBJECT

To investigate the changes in the expression_level of synaptophysin following diffuse brain injury (DBI) in rats and to correlate the changes of the synaptophysin expression_level with the post injury time interval.

METHODS

Wister rats were used as a DBI model induced by Marmarou method. The changes of synaptophysin immunoreactivity on coronal sections of the rats sampled at different post-injury time intervals were used as a marker. The densitometry of the synaptophysin immunoreactivity was documented by imaging technique and analyzed by SPSS software.

RESULTS

The expression level of synaptophysin in DBI rats showed dynamic changes following DBI as well as during the repairing period.

CONCLUSION

The changes of synaptophysin level may be used as a marker for estimation of the post injury time interval in DBI.