[大鼠脑震荡后Bcl-2的表达]
[Bcl-2 expression following the brain concussion in rats].
作者信息
Zhu Xu-yang, Wang Feng, Fang Wei-hua, Wu Mao-wang
机构信息
Department of Forensic Medicine, Wannan Medical College, Wuhu 241001, China.
出版信息
Fa Yi Xue Za Zhi. 2007 Feb 15;23(1):18-9.
OBJECTIVE
To evaluate the expression of Bcl-2 protein after brain concussion.
METHODS
Expression levels of Bel-2 protein in cortex, pontine and cerebellum of rats were investigated using immunohistochemistry.
RESULTS
There was no expression of Bcl-2 protein in control group seen. The expression of Bcl-2 protein in brain concussion groups was detected at l hour, and the expression level reached its peak 4 days after the concussion and then declined gradually.
CONCLUSION
Our findings suggest that the detection of Bel-2 protein could be an indicator for diagnosis of brain concussion and for estimation of the post injury time interval.
目的
评估脑震荡后Bcl-2蛋白的表达情况。
方法
采用免疫组织化学法研究大鼠皮质、脑桥和小脑中Bel-2蛋白的表达水平。
结果
对照组未见Bcl-2蛋白表达。脑震荡组在伤后1小时检测到Bcl-2蛋白表达，伤后4天表达水平达到峰值，随后逐渐下降。
结论
我们的研究结果表明，检测Bel-2蛋白可作为诊断脑震荡及估计伤后时间间隔的一个指标。
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