Mols Floortje, Aaronson Neil K, Vingerhoets Ad J J M, Coebergh Jan-Willem W, Vreugdenhil Gerard, Lybeert Marnix L M, van de Poll-Franse Lonneke V
Comprehensive Cancer Center South, Eindhoven Cancer Registry, Eindhoven, the Netherlands.
Cancer. 2007 Apr 15;109(8):1659-67. doi: 10.1002/cncr.22581.
The objective of this population-based study was to document the long-term effects (5-15 years postdiagnosis) of non-Hodgkin lymphoma and its treatment on health-related quality of life (HRQL) and social problems.
The population-based Eindhoven Cancer Registry was used to select all patients who were diagnosed with non-Hodgkin lymphoma from 1989 to 1998. Three hundred sixty patients were invited to complete the 36-item Short Form Health Survey (SF-36) and the Quality of Life-Cancer Survivors questionnaire, and 294 patients (82%) responded.
Patients who had received chemotherapy reported significantly worse psychological and social well-being and health-related quality of life (HRQL) than patients who had not received chemotherapy. Radiotherapy and watchful waiting were not associated significantly with HRQL outcomes. Patients who were diagnosed from 10 to 15 years earlier reported better social well-being than patients who were diagnosed from 5 to 9 years earlier. Compared with an age-matched, normative sample from the general population, patients reported significantly worse general health and less vitality, but they reported less bodily pain. Practical problems were reported with work (41%), obtaining health care insurance (6%) and life insurance (15%), and obtaining a home mortgage (22%).
From 5 to 15 years after diagnosis, the general health perceptions and vitality levels of non-Hodgkin lymphoma survivors remained significantly lower than those of their peers in the of general population. In addition, survivors faced practical problems with work and finances that deserve additional attention during the period of rehabilitation.
这项基于人群的研究旨在记录非霍奇金淋巴瘤及其治疗对健康相关生活质量（HRQL）和社会问题的长期影响（诊断后5 - 15年）。
利用基于人群的埃因霍温癌症登记处选取1989年至1998年期间所有被诊断为非霍奇金淋巴瘤的患者。邀请360名患者完成36项简短健康调查（SF - 36）和癌症幸存者生活质量问卷，294名患者（82%）做出了回应。
接受化疗的患者在心理和社会幸福感以及健康相关生活质量（HRQL）方面的报告明显比未接受化疗的患者差。放疗和观察等待与HRQL结果无显著关联。诊断时间在10至15年前的患者比诊断时间在5至9年前的患者报告的社会幸福感更好。与来自普通人群的年龄匹配的标准样本相比，患者报告的总体健康状况明显较差，活力较低，但身体疼痛较少。在工作（41%）、获得医疗保险（6%）和人寿保险（15%）以及获得房屋抵押贷款（22%）方面存在实际问题。
在诊断后的5至15年里，非霍奇金淋巴瘤幸存者的总体健康认知和活力水平仍显著低于普通人群中的同龄人。此外，幸存者在工作和财务方面面临实际问题，在康复期间值得给予更多关注。
