Maurer Martin H, Brömme Jens O, Feldmann Robert E, Järve Anne, Sabouri Fatemeh, Bürgers Heinrich F, Schelshorn Dominik W, Krüger Carola, Schneider Armin, Kuschinsky Wolfgang
Department of Physiology and Pathophysiology, Division of Systems Physiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany.
J Proteome Res. 2007 Mar;6(3):1198-208. doi: 10.1021/pr0605825.
On the basis of its inhibition by SB216763, we identified the multifunctional enzyme Glycogen Synthase Kinase 3beta (GSK3beta) as a central regulator for differentiation and cell survival of adult neural stem cells. Detected by proteomic approaches, members of the Wnt/beta-catenin signaling pathway appear to participate in enhanced neuronal differentiation and activated transcription of beta-catenin target genes during GSK3beta inhibition, associated with decreased apoptosis.
基于SB216763对其的抑制作用，我们确定多功能酶糖原合酶激酶3β（GSK3β）是成年神经干细胞分化和细胞存活的核心调节因子。通过蛋白质组学方法检测发现，在GSK3β受到抑制期间，Wnt/β-连环蛋白信号通路的成员似乎参与了增强的神经元分化以及β-连环蛋白靶基因的转录激活，同时细胞凋亡减少。
