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WW domain-containing oxidoreductase promotes neuronal differentiation via negative regulation of glycogen synthase kinase 3β.WW 结构域包含的氧化还原酶通过负向调控糖原合成酶激酶 3β 促进神经元分化。
Cell Death Differ. 2012 Jun;19(6):1049-59. doi: 10.1038/cdd.2011.188. Epub 2011 Dec 23.
2
Inhibition of GSK3β improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome.GSK3β 的抑制作用可改善脆性 X 综合征小鼠模型中海马依赖性学习，并挽救神经发生。
Hum Mol Genet. 2012 Feb 1;21(3):681-91. doi: 10.1093/hmg/ddr501. Epub 2011 Nov 2.
3
Cyanidin-3-glucoside ameliorates ethanol neurotoxicity in the developing brain.矢车菊素-3-葡萄糖苷可改善发育期大脑乙醇神经毒性。
J Neurosci Res. 2011 Oct;89(10):1676-84. doi: 10.1002/jnr.22689. Epub 2011 Jun 10.
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Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3β phosphorylation.颗粒蛋白前体通过磷酸化糖原合成酶激酶 3β 增强神经祖细胞增殖。
Neuroscience. 2011 Jun 30;185:106-15. doi: 10.1016/j.neuroscience.2011.04.037. Epub 2011 Apr 22.
5
Lysophosphatidic acid induces neurite retraction in differentiated neuroblastoma cells via GSK-3β activation.溶血磷脂酸通过激活 GSK-3β诱导分化的神经母细胞瘤细胞轴突回缩。
Mol Cells. 2011 May;31(5):483-9. doi: 10.1007/s10059-011-1036-0. Epub 2011 Apr 14.
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GSK3 signalling in neural development.GSK3 信号在神经发育中的作用。
Nat Rev Neurosci. 2010 Aug;11(8):539-51. doi: 10.1038/nrn2870.
7
LKB1-mediated spatial control of GSK3beta and adenomatous polyposis coli contributes to centrosomal forward movement and neuronal migration in the developing neocortex.LKB1 介导的 GSK3β 和腺瘤性结肠息肉病的空间控制有助于发育中的新皮层中的中心体向前运动和神经元迁移。
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Tau phosphorylation and cleavage in ethanol-induced neurodegeneration in the developing mouse brain.乙醇诱导的发育中鼠脑神经退行性变中的 Tau 磷酸化和裂解。
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9
GSK3beta in ethanol neurotoxicity.糖原合酶激酶3β与乙醇神经毒性
Mol Neurobiol. 2009 Oct;40(2):108-21. doi: 10.1007/s12035-009-8075-y. Epub 2009 Jun 9.
10
Cyanidin-3-glucoside reverses ethanol-induced inhibition of neurite outgrowth: role of glycogen synthase kinase 3 Beta.矢车菊素-3-葡萄糖苷逆转乙醇诱导的神经突生长抑制：糖原合酶激酶 3β的作用。
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糖原合成酶激酶3β在中枢神经系统发育中的作用。

The role of GSK3beta in the development of the central nervous system.

作者信息

Luo Jia

机构信息

Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY 40536, USA.

出版信息

Front Biol (Beijing). 2012 Jun;7(3):212-220. doi: 10.1007/s11515-012-1222-2.

DOI:10.1007/s11515-012-1222-2
PMID:25688261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4327837/
Abstract

Glycogen synthase kinase 3β (GSK3β) is a multifunctional serine/threonine kinase. It is particularly abundant in the developing central nervous system (CNS). Since GSK3β has diverse substrates ranging from metabolic/signaling proteins and structural proteins to transcription factors, it is involved in many developmental events in the immature brain, such as neurogenesis, neuronal migration, differentiation and survival. The activity of GSK3β is developmentally regulated and is affected by various environmental/cellular insults, such as deprivation of nutrients/trophic factors, oxidative stress and endoplasmic reticulum stress. Abnormalities in GSK3β activity may disrupt CNS development. Therefore, GSK3β is a critical signaling protein that regulates brain development. It may also determine neuronal susceptibility to damages caused by various environmental insults.

摘要

糖原合酶激酶3β（GSK3β）是一种多功能丝氨酸/苏氨酸激酶。它在发育中的中枢神经系统（CNS）中特别丰富。由于GSK3β有多种底物，从代谢/信号蛋白、结构蛋白到转录因子，它参与了未成熟大脑中的许多发育事件，如神经发生、神经元迁移、分化和存活。GSK3β的活性受发育调控，并受到各种环境/细胞损伤的影响，如营养/营养因子剥夺、氧化应激和内质网应激。GSK3β活性异常可能会破坏中枢神经系统的发育。因此，GSK3β是调节大脑发育的关键信号蛋白。它还可能决定神经元对各种环境损伤所造成损害的易感性。