Bosselut R, Lim F, Romond P C, Frampton J, Brady J, Ghysdael J
Laboratoire d'Oncologie Virale et Cellulaire, CNRS URA 1443, Institut Curie, Orsay, France.
Virology. 1992 Feb;186(2):764-9. doi: 10.1016/0042-6822(92)90044-p.
The members of the c-myb proto-oncogene family encode sequence-specific transcriptional activators. In T cells, expression of c-myb and the related B-myb gene is induced following mitogenic stimulation. Using a purified recombinant protein, we report here that the human T cell lymphotropic virus type 1 (HTLV-1) LTR contains six specific binding sites for Myb. We also show that HTLV-1 LTR chloramphenicol acetyl transferase reporter plasmids are specifically transactivated by c-Myb. These data suggest a role for members of the Myb family as a link between transcriptional activation of the HTLV-1 LTR and T cell activation events.
c-myb原癌基因家族的成员编码序列特异性转录激活因子。在T细胞中，有丝分裂原刺激后可诱导c-myb及相关B-myb基因的表达。我们在此报道，利用纯化的重组蛋白发现，人类1型嗜T细胞病毒（HTLV-1）长末端重复序列（LTR）含有6个Myb特异性结合位点。我们还表明，HTLV-1 LTR氯霉素乙酰转移酶报告质粒可被c-Myb特异性反式激活。这些数据表明，Myb家族成员在HTLV-1 LTR转录激活与T细胞激活事件之间起到了联系作用。
