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细胞蛋白与人类I型T细胞白血病病毒长末端重复序列U3区域的结合。

Binding of cellular protein(s) to U3 region of human T-cell leukemia virus type-I long terminal repeat.

作者信息

Adachi Y, Hatanaka M

机构信息

Department of Serology and Immunology, Kyoto University, Japan.

出版信息

Virus Genes. 1989 Aug;2(4):307-11. doi: 10.1007/BF00684038.

DOI:10.1007/BF00684038
PMID:2815593
Abstract

The U3 region within the long terminal repeat (LTR) of human T-cell leukemia virus type-I (HTLV-I) contains elements responsible for transcriptional trans-activation. DNA-binding activities of nuclear proteins for each region of LTR were demonstrated using the gel retardation assay. The existence of cellular protein(s) specifically binding to the U3 region was demonstrated. Furthermore, the formation of the U3-protein(s) complex increased remarkably in HTLV-I-infected T-cells.

摘要

人类I型T细胞白血病病毒(HTLV-I)长末端重复序列(LTR)中的U3区域含有负责转录反式激活的元件。使用凝胶阻滞试验证明了核蛋白与LTR各区域的DNA结合活性。证明了存在与U3区域特异性结合的细胞蛋白。此外,在HTLV-I感染的T细胞中,U3-蛋白复合物的形成显著增加。

相似文献

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Virus Genes. 1989 Aug;2(4):307-11. doi: 10.1007/BF00684038.
2
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Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator.人类I型T细胞白血病病毒的p40x是一种反式作用转录激活因子的直接证据。
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10
The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats.人类嗜T淋巴细胞病毒I型(HTLV-I)的pX蛋白是其长末端重复序列的转录激活因子。
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