Puyana Juan Carlos, Pinsky Michael R
Applied Research IMITs Center, Innovative Medical & Information Technology Center, UPMC, F1265 Presbyterian, Pittsburgh, PA 15213-2536, USA.
Crit Care. 2007;11(1):116. doi: 10.1186/cc5691.
Tissue hypoxia is a common end product of circulatory shock and a primary target for resuscitation efforts. In this issue Podbregar and Mozina show that thenar tissue O2 saturation (StO2) and mixed venous O2 saturation (SvO2) co-vary in patients in left ventricular failure, but in patients with sepsis StO2 was higher than SvO2. Although StO2 may co-vary with SvO2 they have different determinants such that after shock StO2 may increase well before SvO2 as a result of increased O2 demands to repay O2 debt incurred during hypoperfusion. Thus, the use of StO2 alone to define the endpoint of resuscitation may be misleading.
组织缺氧是循环性休克常见的最终结果,也是复苏努力的主要目标。在本期中,波德布雷加尔和莫齐纳表明,在左心室衰竭患者中,鱼际组织氧饱和度(StO2)和混合静脉血氧饱和度(SvO2)共同变化,但在脓毒症患者中,StO2高于SvO2。尽管StO2可能与SvO2共同变化,但它们有不同的决定因素,因此休克后,由于偿还低灌注期间产生的氧债所需的氧需求增加,StO2可能在SvO2之前就大幅升高。因此,仅使用StO2来定义复苏终点可能会产生误导。