Xie Yan-chen, Jiao Yu-juan, Xu Xian-hao, Wang Hong, Yin Jian
Department of Neurology, Beijing Hospital, Beijing 100730, China.
Zhonghua Nei Ke Za Zhi. 2007 Jan;46(1):56-9.
To evaluate the expression of glucocorticoid receptor (GR) alpha and GRbeta in peripheral blood mononuclear cells (PBMC) from patients of myasthenia gravis (MG). To investigate the relationship between the expression level of GR and glucocorticoid (GC) therapeutic effects to MG patients.
The clinical score was recorded and used to assessing the therapeutic effects. Then the expression level of GRalpha and GRbeta in PBMC by immunocytochemistry was measured. We analysed the relationship of the therapeutic effects with expression level of GR.
The scores of GRalpha positive PBMC score were same in healthy-control group, GC sensitive group, and GC dependent group. But GRalpha positive PBMC score in GC resistance group was decreased compared with the others (P < 0.01). The scores of GRbeta positive PBMC score were same in healthy-control group, GC sensitive group, and GC resistant group. But GRbeta positive PBMC score in GC dependent group was increased compared with the others (P < 0.01).
The expression of GRalpha in GC resistant group are decreased, and the expression of GRbeta in GC dependence group is increased. The expression level of GRalpha or GRbeta is associated with the effect of GC in treatment of MG.
评估重症肌无力（MG）患者外周血单个核细胞（PBMC）中糖皮质激素受体（GR）α和GRβ的表达情况。探讨GR表达水平与糖皮质激素（GC）对MG患者治疗效果之间的关系。
记录临床评分并用于评估治疗效果。然后通过免疫细胞化学法检测PBMC中GRα和GRβ的表达水平。分析治疗效果与GR表达水平之间的关系。
健康对照组、GC敏感组和GC依赖组中GRα阳性PBMC评分相同。但GC抵抗组中GRα阳性PBMC评分低于其他组（P<0.01）。健康对照组、GC敏感组和GC抵抗组中GRβ阳性PBMC评分相同。但GC依赖组中GRβ阳性PBMC评分高于其他组（P<0.01）。
GC抵抗组中GRα表达降低，GC依赖组中GRβ表达增加。GRα或GRβ的表达水平与GC治疗MG的效果相关。
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