甲硝唑治疗后细菌性阴道病女性孕早期合法堕胎后盆腔炎的发生率：一项双盲随机研究
Incidence of pelvic inflammatory disease after first-trimester legal abortion in women with bacterial vaginosis after treatment with metronidazole: a double-blind, randomized study.
作者信息
Larsson P G, Platz-Christensen J J, Thejls H, Forsum U, Påhlson C
机构信息
Department of Obstetrics and Gynecology, Central Hospital, Skövde, Sweden.
出版信息
Am J Obstet Gynecol. 1992 Jan;166(1 Pt 1):100-3. doi: 10.1016/0002-9378(92)91838-2.
OBJECTIVE
The purpose of this study was to evaluate the effect of metronidazole treatment on the incidence of postoperative pelvic inflammatory disease after first-trimester abortion in women with bacterial vaginosis.
STUDY DESIGN
A double-blind, randomized, multicenter study was conducted on 231 women undergoing first-trimester legal abortion and fulfilling the criteria for bacterial vaginosis. The women were randomized to either metronidazole 500 mg three times daily for 10 days or placebo. Treatment was started at the outpatient visit the week before the operation.
RESULTS
Among the 174 women who could be evaluated, pelvic inflammatory disease developed in 14 after the abortion. In the treatment group there were three infections (3.8%) compared with 11 (12.2%) in the placebo group (p less than 0.05).
CONCLUSION
These data suggest that patients with bacterial vaginosis should be treated in conjunction with first-trimester abortion because treatment with metronidazole reduces the postoperative infection rate more than three times.
目的
本研究旨在评估甲硝唑治疗对患有细菌性阴道病的孕早期流产女性术后盆腔炎发病率的影响。
研究设计
对231名接受孕早期合法流产且符合细菌性阴道病标准的女性进行了一项双盲、随机、多中心研究。这些女性被随机分为两组，一组每天三次服用500毫克甲硝唑，共10天，另一组服用安慰剂。治疗在手术前一周的门诊就诊时开始。
结果
在174名可评估的女性中，有14名在流产后发生了盆腔炎。治疗组有3例感染（3.8%），而安慰剂组有11例（12.2%）（p<0.05）。
结论
这些数据表明，患有细菌性阴道病的患者在进行孕早期流产时应接受治疗，因为甲硝唑治疗可将术后感染率降低三倍以上。
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