小鼠发育植入后即刻胚胎发生期的基因表达模式与胚胎发育进程

Gene expression pattern and progression of embryogenesis in the immediate post-implantation period of mouse development.

作者信息

Pfister Sabine, Steiner Kirsten A, Tam Patrick P L

机构信息

Embryology Unit, Children's Medical Research Institute, University of Sydney, Locked Bag 23, Wentworthville, NSW 2145, Australia.

出版信息

Gene Expr Patterns. 2007 Apr;7(5):558-73. doi: 10.1016/j.modgep.2007.01.005. Epub 2007 Jan 27.

DOI:10.1016/j.modgep.2007.01.005

PMID:17331809

Abstract

During development of the mouse conceptus from implantation to the early gastrula stage, a multitude of genes encoding structural proteins, transcription factors and components of signalling pathways are expressed in the extraembryonic and embryonic tissues derived from the trophectoderm and the inner cell mass. Some genes are expressed widely in the extraembryonic ectoderm, the visceral endoderm or the epiblast, while others display more restricted expression domains in these tissues or are expressed upon the specification of the germ layers at gastrulation. Overall, the developmental changes in gene expression mirror key events of embryogenesis, and reveal the regionalization of signalling activity and the emergence of tissue patterning.

摘要

在小鼠胚胎从着床到原肠胚早期的发育过程中，许多编码结构蛋白、转录因子和信号通路成分的基因在源自滋养外胚层和内细胞团的胚外组织和胚胎组织中表达。一些基因在胚外外胚层、脏内胚层或上胚层中广泛表达，而其他基因在这些组织中表现出更局限的表达域，或者在原肠胚形成时胚层特化时表达。总体而言，基因表达的发育变化反映了胚胎发生的关键事件，并揭示了信号活性的区域化和组织模式的出现。