接受二次剖腹探查术的卵巢癌患者血清巨噬细胞集落刺激因子水平

Serum levels of macrophage colony-stimulating factor in patients with ovarian cancer undergoing second-look laparotomy.

作者信息

Elg S A, Yu Y, Carson L F, Adcock L L, Twiggs L B, Prem K A, Ramakrishnan S

机构信息

Women's Cancer Center, University of Minnesota Health Science Center, Minneapolis 55455.

出版信息

Am J Obstet Gynecol. 1992 Jan;166(1 Pt 1):134-7. doi: 10.1016/0002-9378(92)91846-3.

DOI:10.1016/0002-9378(92)91846-3

PMID:1733183

Abstract

OBJECTIVE

The purpose of this study was to evaluate the prognostic significance of macrophage colony-stimulating factor serum levels in patients with ovarian cancer undergoing second-look laparotomy.

STUDY DESIGN

The presurgical serum levels of macrophage colony-stimulating factor from 33 consecutive patients with ovarian cancer undergoing second-look laparotomy were determined and compared with those of 50 healthy control subjects. Mean differences in groups were evaluated with the Student t test.

RESULTS

Sixteen of 33 patients had a positive result at second look and a mean serum macrophage colony-stimulating factor level of 2.31 +/- 1.45 ng/ml. Seventeen of 33 patients had a negative result at second look and a mean macrophage colony-stimulating factor level of 1.90 +/- 0.86 ng/ml (p greater than 0.05). The mean macrophage colony-stimulating factor level in the control group was 1.20 +/- 0.51 ng/ml. This was statistically lower than the mean level found in patients with a negative second-look result (p less than 0.05).

CONCLUSION

Regardless of tumor status, serum macrophage colony-stimulating factor levels tend to be elevated at the time of second-look laparotomy.

摘要

目的

本研究旨在评估接受二次剖腹探查术的卵巢癌患者血清巨噬细胞集落刺激因子水平的预后意义。

研究设计

测定了33例连续接受二次剖腹探查术的卵巢癌患者术前血清巨噬细胞集落刺激因子水平，并与50名健康对照者的水平进行比较。采用学生t检验评估组间平均差异。

结果

33例患者中有16例二次探查结果为阳性，血清巨噬细胞集落刺激因子平均水平为2.31±1.45 ng/ml。33例患者中有17例二次探查结果为阴性，巨噬细胞集落刺激因子平均水平为1.90±0.86 ng/ml（p>0.05）。对照组巨噬细胞集落刺激因子平均水平为1.20±0.51 ng/ml。这在统计学上低于二次探查结果为阴性的患者的平均水平（p<0.05）。