Broekema W J, de Groot I W, van Harten P N
Symfora group, Centres for Mental Healthcare, Amersfoort, The Netherlands.
Pharm World Sci. 2007 Jun;29(3):126-30. doi: 10.1007/s11096-006-9063-1. Epub 2007 Feb 27.
The aim of this study was to investigate to what extent atypical antipsychotics, conventional antipsychotics and anticholinergics are prescribed simultaneously in daily clinical practice in Europe.
A pharmaco-epidemiological study was carried out in which hospital pharmacists from 45 hospitals in Belgium, Denmark, France, Germany, The Netherlands and Scotland participated. Prescription data for 2,725 patients (mainly inpatients) who had been using an atypical antipsychotic for more than 6 weeks were analysed.
The frequencies of simultaneous prescription of atypical antipsychotics with other antipsychotics and/or anticholinergics.
In this sample of patients with an atypical antipsychotic 42.1% was prescribed another antipsychotic (24.1% if low-potent antipsychotics were not included in the analysis) and 30.1% was prescribed an anticholinergic. In total 47.1% of patients were prescribed an atypical antipsychotic without any other antipsychotic or anticholinergic.
It is common practice to prescribe a combination of atypical antipsychotics and conventional antipsychotics and/or anticholinergics. This suggests that monotherapy involving an atypical antipsychotic is not considered to be an adequate treatment for a substantial number of patients in clinical practice.
本研究旨在调查在欧洲日常临床实践中，非典型抗精神病药物、传统抗精神病药物和抗胆碱能药物同时开具处方的程度。
开展了一项药物流行病学研究，比利时、丹麦、法国、德国、荷兰和苏格兰的45家医院的医院药剂师参与其中。分析了2725名使用非典型抗精神病药物超过6周的患者（主要是住院患者）的处方数据。
非典型抗精神病药物与其他抗精神病药物和/或抗胆碱能药物同时开具处方的频率。
在这个使用非典型抗精神病药物的患者样本中，42.1%的患者还开具了另一种抗精神病药物（如果分析中不包括低效价抗精神病药物，则为24.1%），30.1%的患者开具了抗胆碱能药物。总共有47.1%的患者仅开具了非典型抗精神病药物，未开具任何其他抗精神病药物或抗胆碱能药物。
同时开具非典型抗精神病药物与传统抗精神病药物和/或抗胆碱能药物是常见的做法。这表明在临床实践中，对于相当一部分患者而言，使用非典型抗精神病药物进行单一疗法被认为并非充分的治疗方法。
