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接受健康检查的泰国男性和女性中高胆固醇血症的患病率及危险因素。

Prevalence and risk factors of hypercholesterolemia among Thai men and women receiving health examinations.

作者信息

Le Denny, Garcia Alvin, Lohsoonthorn Vitool, Williams Michelle A

机构信息

Department of Epidemiology, Multidisciplinary International Research Training Program, University of Washington School of Public Health and Community Medicine, Seattle, Washington, USA.

出版信息

Southeast Asian J Trop Med Public Health. 2006 Sep;37(5):1005-14.

Abstract

The purpose of our study was to evaluate risk factors for hypercholesterolemia and correlates of serum lipid concentrations in Thai men and women. A cross-sectional study was conducted in 1392 patients (380 men and 1012 women) who received health examinations during July 1999 - February 2000 at King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Serum total cholesterol (TC), triglyceride (TG) and high density lipoprotein- cholesterol (HDL-C) concentrations were determined using standard procedures. Logistic and linear regression procedures were used to assess the association of several covariates with risk for hypercholesterolemia. The results reveal that the prevalences of hypercholesterolemia (TC > or =200 mg/dl) among men and women were 66.8% and 66.0%, respectively. Among men, hypercholesterolemia was associated with older adults (OR = 3.26), and previous alcohol consumption (OR = 2.05). Risk factors for women included advanced age (OR = 3.19), and a family history of dyslipidemia (OR = 1.59). Serum TC and TG were positively associated with age and previous alcohol consumption among men. Among women, TC and TG were strongly associated with age, body mass index (BMI) and family history of dyslipidemia. In men and women, HDL-C was inversely associated with BMI. More emphasis should be placed on understanding the epidemiology of hypercholesterolemia and other dyslipidemias in Thai men and women. More information regarding risk factors will aid in the development of effective health promotion and disease prevention efforts.

摘要

我们研究的目的是评估泰国男性和女性高胆固醇血症的危险因素以及血清脂质浓度的相关因素。对1392名患者(380名男性和1012名女性)进行了一项横断面研究,这些患者于1999年7月至2000年2月在泰国曼谷朱拉隆功国王纪念医院接受了健康检查。采用标准程序测定血清总胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白胆固醇(HDL-C)浓度。使用逻辑回归和线性回归程序评估几种协变量与高胆固醇血症风险的关联。结果显示,男性和女性中高胆固醇血症(TC≥200mg/dl)的患病率分别为66.8%和66.0%。在男性中,高胆固醇血症与老年人(OR=3.26)和既往饮酒(OR=2.05)有关。女性的危险因素包括高龄(OR=3.19)和血脂异常家族史(OR=1.59)。男性的血清TC和TG与年龄和既往饮酒呈正相关。在女性中,TC和TG与年龄、体重指数(BMI)和血脂异常家族史密切相关。在男性和女性中,HDL-C与BMI呈负相关。应更加重视了解泰国男性和女性高胆固醇血症及其他血脂异常的流行病学。更多关于危险因素的信息将有助于开展有效的健康促进和疾病预防工作。

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