Shan Yisheng, Tian Xinkui, Wang Tao
Institute of Nephrology, First Hospital, Peking University, Beijing 100034, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2007 Feb;24(1):140-4.
Urea clearance index (KT/Vurea) and creatinine clearance weekly (Ccr) are main indexes to evaluate dialysis adequacy. In order to discuss whether they are suitable to evaluate peritoneal dialysis adequacy, we applied trans-peritoneum transport kinetic model and explored the transport characteristics of fluid and various solutes. We found that: (1) There was no specific relationship among the removal of solutes with different molecular weights; (2) There was significant difference between urea removal and fluid and sodium removal. Our results suggest that urea and creatinine removal do not represent other solutes and fluid removal. KT/Vurea and Ccr may thus not suit to be used alone to evaluate peritoneal dialysis adequacy.
尿素清除指数（KT/Vurea）和每周肌酐清除率（Ccr）是评估透析充分性的主要指标。为探讨它们是否适用于评估腹膜透析充分性，我们应用经腹膜转运动力学模型，探究了液体及各种溶质的转运特性。我们发现：（1）不同分子量溶质的清除之间不存在特定关系；（2）尿素清除与液体及钠清除之间存在显著差异。我们的结果表明，尿素和肌酐的清除并不代表其他溶质和液体的清除。因此，KT/Vurea和Ccr可能不适宜单独用于评估腹膜透析充分性。
