[脉冲电场的生物学效应及其在医学中的应用]

[Biological effects and their applications in medicine of pulsed electric fields].

作者信息

Huang Hua, Song Guanbin, Wang Guixue, Sun Caixin

机构信息

Key Laboratory for Biomnechanics & Tissue Engineering of the State Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2007 Feb;24(1):230-4.

PMID:17333929

Abstract

Pulsed electric fields can induce various kinds of biological effects that are essentially different from the normal electric fields, especially the interactions of Nanosecond Pulsed electric field (nsPEF) with cells. The biological effects of different pulsed electric fields on cell membranes, cytoplasmic matrixes, cell growth are introduced in this paper. Based on these effects, some applications of pulsed electric fields in cancer therapy, gene therapy, and delivery of drugs are reviewed in details.

摘要

脉冲电场可诱导出各种与正常电场本质不同的生物效应，尤其是纳秒脉冲电场（nsPEF）与细胞的相互作用。本文介绍了不同脉冲电场对细胞膜、细胞质基质、细胞生长的生物效应。基于这些效应，详细综述了脉冲电场在癌症治疗、基因治疗和药物递送方面的一些应用。