Yamaguchi Keizo, Ohno Akira, Ishii Yoshikazu, Tateda Kazuhiro, Iwata Morihiro, Kanda Makoto, Tsujio Yoshiko, Kimoto Hiroya, Kaimori Mitsuomi, Nakamura Toshihiko, Kawamura Chizuko, Nishimura Masaharu, Akizawa Koji, Katayama Yosei, Matsuda Keiko, Hayashi Tasuku, Yasujima Minoru, Kasai Takeshi, Kimura Masahiko, Tominaga Makoto, Miki Makoto, Nakanowatari Susumu, Nakagawa Takuo, Kaku Mitsuo, Kanemitsu Keiji, Kunishima Hiroyuki, Toyoshima Shunkoh, Sakurai Masanori, Shiotani Joji, Sugita Akihiro, Ito Tatsumi, Okada Jun, Suwabe Akira, Yamahata Kumiko, Yoneyama Akiko, Kumasaka Kazunari, Yamane Nobuo, Koike Kazuhiko, Ieiri Tamio, Kominami Hidenori, Yamada Toshiyuki, Oguri Toyoko, Itoh Kouichi, Watanabe Kiyoaki, Kobayashi Yoshio, Ohtake Teruko, Uchida Takashi, Totsuka Kyoichi, Murakami Masami, Yomoda Sachie, Takahashi Ayako, Okamoto Hideyuki, Inuzuka Kazuhisa, Yamazaki Kenichiro, Gonda Hideo, Yamashita Takanori, Yamaguchi Ikuo, Okada Motoi, Ikari Hiromi, Kurosawa Naomi, Fujimoto Yoshinori, Ishigo Shiomi, Asano Yuko, Mikio Mori, Kano Ichino, Nagano Eiko, Kageyama Fumio, Shaku Etsuko, Kanno Harushige, Aihara Masanori, Gemma Hitoshi, Uemura Keiichi, Miyajima Eiji, Maesaki Shighefumi, Hashikita Giichi, Horii Toshinobu, Sumitomo Midori, Yoshimura Hitoshi, Hiraoka Minoru, Wada Hideo, Yuzuki Yosuke, Ikeda Norio, Baba Hisashi, Soma Masayuki, Yamamoto Tsuyoshi, Ichiyama Satoshi, Kinosita Syohiro, Kawano Seiji, Fujita Shinichi, Kageoka Takeshi, Hongo Toshiharu, Okabe Hidetoshi, Tatewaki Kenichi, Moro Kunihiko, Oka Mikio, Niki Yoshihito, Yoshida Haruyoshi, Yamashita Masanobu, Kusano Nobuchika, Mihara Eiichiro, Nose Motoko, Fushiwaki Takeshi, Kuwabara Masao, Fujiue Yoshihiro, Shimuzu Akira, Takubo Takayuki, Kusakabe Tadashi, Hinoda Yuji, Tanaka Nobuaki, Takahashi Hakuo, Heijyou Hitoshi, Okazaki Toshiro, Asai Koji, Kawahara Kunimitsu, Masuda Junichi, Sano Reiko, Taminato Tomohiko, Negayama Kiyoshi, Matsuo Syuji, Komatsu Masaru, Sugiura Tetsuro, Murase Mitsuharu, Hiramatsu Kazufumi, Yamane Nobuhisa, Nakasone Isao, Hirakata Yoichi, Kohno Shigeru, Aizawa Hisamichi, Honda Junichi, Hamazaki Naotaka, Okayama Akihiko, Ono Junko, Aoki Yosuke, Okada Kaoru, Miyanohara Hiroaki
Department of Microbiology and Infectious Diseases, Toho University Faculty of Medicine.
Jpn J Antibiot. 2006 Dec;59(6):428-51.
A total of 18,639 clinical isolates in 19 species collected from 77 centers during 2004 in Japan were tested for their susceptibility to fluoroquinolones (FQs) and other selected antibiotics. The common respiratory pathogens, Streptococcus pyogenes, Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenzae showed a high susceptible rate against FQs. The isolation rate of beta lactamase non-producing ampicillin-resistant H. influenzae was approximately three times as large as those of western countries. Most strains of Enterobacteriaceae were also susceptible to FQs. The resistance rate of Escherichia coli against FQs has however been rapidly increasing so far as we surveyed since 1994. The FQs-resistant rate in methicillin-resistant Staphylococcus aureus (MRSA) showed approximately 90% except for 36%. of sitafloxacin while FQs-resistant rate in methicillin-susceptible S. aureus (MSSA) was around 5%. The FQs-resistant rate of methicillin-resistant coagulase negative Staphylococci (MRCNS) was also higher than that of methicillin-susceptible coagulase negative Staphylococci (MSCNS), however, it was lower than that of MRSA. In Pseudomonas aeruginosa clinical isolates, 32-34% from UTI and 15-19% of from RTI was resistant to FQs. Acinetobacter spp. showed a high susceptibility to FQs. Although FQs-resistant Neisseria gonorrhoeae have not been increased in western countries, it is remarkably high in Japan. In this survey, isolates of approximately 85% was resistant to FQs.
2004年期间，从日本77个中心收集了19个菌种的总共18639株临床分离菌，检测了它们对氟喹诺酮类药物（FQs）和其他选定抗生素的敏感性。常见呼吸道病原体化脓性链球菌、肺炎链球菌、卡他莫拉菌和流感嗜血杆菌对FQs显示出高敏感率。不产β-内酰胺酶的氨苄西林耐药流感嗜血杆菌的分离率约为西方国家的三倍。大多数肠杆菌科菌株也对FQs敏感。然而，自1994年我们开展调查以来，大肠杆菌对FQs的耐药率一直在迅速上升。耐甲氧西林金黄色葡萄球菌（MRSA）对FQs的耐药率除司帕沙星为36%外显示约为90%，而甲氧西林敏感金黄色葡萄球菌（MSSA）对FQs的耐药率约为5%。耐甲氧西林凝固酶阴性葡萄球菌（MRCNS）对FQs的耐药率也高于甲氧西林敏感凝固酶阴性葡萄球菌（MSCNS），然而，低于MRSA。在铜绿假单胞菌临床分离株中，32%-34%的泌尿道感染分离株和15%-19%的呼吸道感染分离株对FQs耐药。不动杆菌属对FQs显示出高敏感性。虽然西方国家耐FQs淋病奈瑟菌未增加，但在日本其比例非常高。在本次调查中，约85%的分离株对FQs耐药。
