Shinagawa Nagao, Yura Jiro, Takeyama Hiromitsu, Taniguchi Masaaki
Department of Surgery, Nagoya Midori Municipal Hospital.
Jpn J Antibiot. 2006 Dec;59(6):452-8.
Bilophila wadsworthia is a recently recognized nonspore-forming anaerobic Gram-negative rod and is reported to be associated with various surgical infections. In the present study, the isolation rate of B. wadsworthia from surgical specimens and its antimicrobial susceptibilities were examined. Last 5 years, B. wadsworthia was isolated from 46 (5.2%) out of 884 specimens from the surgical abdominal infections. B. wadsworthia was most frequently isolated from secondary peritonitis such as perforated peritonitis, followed by postoperative peritonitis. There is no case of single isolation of B. wadsworthia. The rate of mixed infection with Bacteroides spp. (24.8%) was highest, followed by Escherichia coli (11.6%) and Enterococcus spp. (10.1%). Although B. wadsworthia was highly resistant to many beta-lactam antibiotics, clindamycin showed strongest activities with MIC90 of 1 microg/mL, followed by minocycline and ciprofloxacin with 4micro g/mL, and levofloxacin with 8 microg/mL, respectively.
沃兹沃思嗜胆菌是一种最近才被认识的无芽孢形成的厌氧革兰氏阴性杆菌，据报道与各种外科感染有关。在本研究中，检测了从手术标本中分离出沃兹沃思嗜胆菌的比率及其抗菌药敏性。在过去5年中，从884份腹部手术感染标本中有46份（5.2%）分离出了沃兹沃思嗜胆菌。沃兹沃思嗜胆菌最常从继发性腹膜炎如穿孔性腹膜炎中分离出来，其次是术后腹膜炎。没有单独分离出沃兹沃思嗜胆菌的病例。与拟杆菌属的混合感染率（24.8%）最高，其次是大肠杆菌（11.6%）和肠球菌属（10.1%）。虽然沃兹沃思嗜胆菌对许多β-内酰胺类抗生素高度耐药，但克林霉素显示出最强的活性，其MIC90为1微克/毫升，其次是米诺环素和环丙沙星，MIC90分别为4微克/毫升和左氧氟沙星，MIC90为8微克/毫升。
