嗜胆菌在中国引起菌血症的首例病例报告及文献综述。
First case report of bacteremia caused by Bilophila wadsworthia in China, and literature review.
作者信息
Gan Fangrong, Luo Shuang, Wei Xiaoxun, Zuo Shuguang
机构信息
Department of clinical laboratory, LiuZhou Municipal Liutie Central Hospital, NO 14, Egang R.d, Liunan district, Liuzhou, Guangxi Zhuang Autonomous Region, 545005, China.
出版信息
BMC Infect Dis. 2025 Feb 5;25(1):168. doi: 10.1186/s12879-025-10570-w.
Bilophila wadsworthia is rarely found in the bloodstream. We report the first case of bloodstream infection caused by B. wadsworthia in a diabetic foot patient in China. B. wadsworthia is a normal component of the human intestinal microbiota, and a history of diarrhea may contribute to its translocation into the bloodstream. Due to the slow growth of B. wadsworthia, prolonged incubation was essential for its detection. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) enabled rapid identification of the pathogen. Early initiation of Piperacillin/Tazobactam therapy resulted in a favorable clinical outcome.
沃兹沃思嗜胆菌很少在血液中被发现。我们报告了中国首例糖尿病足患者由沃兹沃思嗜胆菌引起的血流感染病例。沃兹沃思嗜胆菌是人类肠道微生物群的正常组成部分，腹泻病史可能促使其易位进入血液。由于沃兹沃思嗜胆菌生长缓慢，延长培养时间对其检测至关重要。基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF MS）能够快速鉴定病原体。早期开始使用哌拉西林/他唑巴坦治疗取得了良好的临床效果。
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