肾上腺嗜铬细胞瘤中HMB-45的反应性
HMB-45 reactivity in adrenal pheochromocytomas.
作者信息
Unger P D, Hoffman K, Thung S N, Pertsemlides D, Wolfe D, Kaneko M
机构信息
Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai School of Medicine, City University of New York.
出版信息
Arch Pathol Lab Med. 1992 Feb;116(2):151-3.
Melanoma-specific antibody (HMB-45) is highly specific for junctional nevi, malignant melanomas, and related lesions. Rarely have other benign or neoplastic tissues demonstrated positivity with the monoclonal antibody following purification. In the present study, four of 12 pheochromocytomas contained chief cells that reacted with HMB-45. We discuss the clinical and pathologic implications of this finding.
黑色素瘤特异性抗体（HMB - 45）对交界痣、恶性黑色素瘤及相关病变具有高度特异性。纯化后的单克隆抗体极少在其他良性或肿瘤性组织中显示阳性。在本研究中，12例嗜铬细胞瘤中有4例的主细胞与HMB - 45发生反应。我们讨论了这一发现的临床和病理意义。
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