Oda Yoshinao, Izumi Teiyu, Harimaya Katsumi, Segawa Yuichi, Ishihara Shinichiro, Komune Shizuo, Iwamoto Yukihide, Tsuneyoshi Masazumi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Mod Pathol. 2007 May;20(5):545-51. doi: 10.1038/modpathol.3800770. Epub 2007 Mar 2.
We herein describe three cases of pigmented villonodular synovitis with chondroid metaplasia. Two cases involved the temporomandibular joint, whereas the remaining one case occurred in the hip joint. Histologically, the tumors showed a villous pattern and were mainly composed of histiocyte-like cells and scattered osteoclast-like multinucleated giant cells, accompanied by chondroid areas with occasional lace-like calcification. These features resembled those of chondroblastoma of the bone, with the exception of the villous pattern. The histiocyte-like cells showed positive immunoreactivity for CD68, whereas they were negative for S-100 protein. Some of the previously reported cases of chondroblastoma in the temporal bone may have actually been cases of pigmented villonodular synovitis with chondroid metaplasia. When histologically chondroblastoma-like lesions involve the temporal bone or temporomandibular joint, the possibility of pigmented villonodular synovitis with chondroid metaplasia should also be considered, in addition to chondroblastoma of the bone. The correlation between this lesion and synovial chondromatosis remains uncertain.
我们在此描述三例伴有软骨化生的色素沉着绒毛结节性滑膜炎。两例累及颞下颌关节，另一例发生于髋关节。组织学上，肿瘤呈绒毛状，主要由组织细胞样细胞和散在的破骨细胞样多核巨细胞组成，伴有软骨样区域，偶见花边样钙化。这些特征与骨软骨母细胞瘤相似，但有绒毛状结构除外。组织细胞样细胞CD68免疫反应阳性，而S-100蛋白免疫反应阴性。一些先前报道的颞骨软骨母细胞瘤病例实际上可能是伴有软骨化生的色素沉着绒毛结节性滑膜炎。当组织学上类似软骨母细胞瘤的病变累及颞骨或颞下颌关节时，除骨软骨母细胞瘤外，还应考虑伴有软骨化生的色素沉着绒毛结节性滑膜炎的可能性。该病变与滑膜软骨瘤病之间的相关性仍不确定。
