Grillo M A, Colombatto S
Dipartimento di Medicina e Oncologia Sperimentale, Sezione di Biochimica, Università di Torino, Torino, Italy.
Amino Acids. 2008 Feb;34(2):187-93. doi: 10.1007/s00726-007-0500-9. Epub 2007 Mar 3.
S-adenosylmethionine is involved in many processes, mainly methylation, polyamine synthesis and radical-based catalysis. It is synthesised through the catalysis of differently regulated enzyme forms. When it is used, the compounds formed are reutilized in different ways: in case of methylation, its end product is homocysteine, which can be remethylated to methionine, give rise to cysteine in the so-called transsulphuration pathway, or be released; in the case of polyamine synthesis, the methylthioadenosine formed is cleaved and gives rise to compounds which can be reutilized; during radical-based catalysis, 5-deoxyadenosine is formed and this, too, is cleaved and reutilized.
S-腺苷甲硫氨酸参与许多过程，主要是甲基化、多胺合成和基于自由基的催化作用。它是通过不同调节的酶形式催化合成的。当它被利用时，形成的化合物以不同方式被再利用：在甲基化的情况下，其终产物是同型半胱氨酸，它可以再甲基化生成甲硫氨酸，在所谓的转硫途径中生成半胱氨酸，或者被释放；在多胺合成的情况下，形成的甲硫基腺苷被裂解并产生可再利用的化合物；在基于自由基的催化过程中，形成5-脱氧腺苷，它也会被裂解并再利用。
