Len Oscar, Pahissa Albert
Servicio Enfermedades Infecciosas, Hospital Vall d'Hebron, Barcelona, España.
Enferm Infecc Microbiol Clin. 2007 Mar;25(3):204-12. doi: 10.1016/s0213-005x(07)74262-3.
The defence response to infectious agents is compromised in solid organ recipients because of their immunosuppressive treatment. Transmission of infection from a donor organ can result in dysfunction or loss of the allograft, and may lead to death of the recipient if adequate preventive measures are not taken. This potential risk should be thoroughly assessed, particularly in the case of organs from infected donors, in order to optimize organ use without increasing the incidence of graft dysfunction and recipient morbidity and mortality. This article reviews the current knowledge regarding screening for infection in potential donors and discusses risk-benefit considerations related to the use of organs from infected donors.
由于接受实体器官移植的患者接受免疫抑制治疗,其对感染因子的防御反应受到损害。来自供体器官的感染传播可导致同种异体移植物功能障碍或丧失,如果不采取适当的预防措施,可能导致受者死亡。应全面评估这种潜在风险,特别是对于来自感染供体的器官,以便在不增加移植物功能障碍发生率以及受者发病率和死亡率的情况下优化器官的使用。本文综述了有关潜在供体感染筛查的现有知识,并讨论了与使用来自感染供体的器官相关的风险效益考量。