桥本脑病中针对α-烯醇化酶氨基末端的血清自身抗体高流行率。

High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in Hashimoto's encephalopathy.

作者信息

Yoneda M, Fujii A, Ito A, Yokoyama H, Nakagawa H, Kuriyama M

机构信息

Second Department of Internal Medicine (Neurology), Faculty of Medical Sciences, University of Fukui, Fukuii 910-1193, Japan.

出版信息

J Neuroimmunol. 2007 Apr;185(1-2):195-200. doi: 10.1016/j.jneuroim.2007.01.018. Epub 2007 Mar 1.

DOI:10.1016/j.jneuroim.2007.01.018

PMID:17335908

Abstract

Recently, we discovered autoantibodies against the amino (NH(2))-terminal of alpha-enolase (NAE) in patients with Hashimoto's encephalopathy (HE) (83.3%; 5/6) [Fujii, A., Yoneda, M., Ito, T., Yamamura, O., Satomi, S., Higa, H., Kimura, M., Suzuki, M., Yamashita, M., Yuasa, T., Suzuki, H., Kuriyama, M., 2005. Autoantibodies against the amino terminal of alpha-enolase are a useful diagnostic marker of Hashimoto's encephalopathy. J. Neuroimmunol. 162, 130-136]. We further investigated the anti-NAE autoantibodies in 25 patients who fit the diagnostic criteria for HE, based on the presence of anti-thyroid antibodies and responsiveness to immunotherapy. In this study, we demonstrated a high prevalence (68%, 17 of 25) and high specificity of anti-NAE autoantibodies in patients with HE, and clarified the clinical features of HE. This result demonstrated that anti-NAE autoantibodies, in addition to anti-thyroid autoantibodies, are emphasized as useful serological diagnostic markers of HE.

摘要

最近，我们在桥本脑病（HE）患者中发现了针对α-烯醇化酶（NAE）氨基（NH₂）末端的自身抗体（83.3%；6例中有5例）[藤井，A.，米田，M.，伊藤，T.，山村，O.，里见，S.，日高，H.，木村，M.，铃木，M.，山下，M.，汤浅，T.，铃木，H.，栗山，M.，2005年。针对α-烯醇化酶氨基末端的自身抗体是桥本脑病的一种有用诊断标志物。《神经免疫学杂志》162，130 - 136]。基于抗甲状腺抗体的存在和对免疫治疗的反应性，我们进一步研究了25例符合HE诊断标准患者的抗NAE自身抗体。在本研究中，我们证实了HE患者中抗NAE自身抗体的高患病率（68%，25例中有17例）和高特异性，并阐明了HE的临床特征。该结果表明，除了抗甲状腺自身抗体外，抗NAE自身抗体也被视为HE有用的血清学诊断标志物。