表皮生长因子对大鼠放射性口腔黏膜炎的影响。
Effect of epidermal growth factor against radiotherapy-induced oral mucositis in rats.
作者信息
Lee Sang-Wook, Jung Kwon Il, Kim Yeun Wha, Jung Heun Don, Kim Hyun Sook, Hong Joon Pio
机构信息
Department of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
出版信息
Int J Radiat Oncol Biol Phys. 2007 Mar 15;67(4):1172-8. doi: 10.1016/j.ijrobp.2006.10.038.
PURPOSE
We tested the efficacy of oral recombinant human epidermal growth factor (rhEGF) against radiation-induced oral mucositis in a rat model.
METHODS AND MATERIALS
Each of 35 Sprague-Dawley rats, 7 to 8 weeks of age and weighing 178 +/- 5 grams, was irradiated once in the head region with 25 Gy, using a 4-MV therapeutic linear accelerator at a rate of 2 Gy/min. The irradiated rats were randomly divided into four groups: those receiving no treatment (Group 1), those treated with vehicle only three times per day (Group 2), and those treated with 50 microg/mL (Group 3), or 100 microg/mL (Group 4) rhEGF three times per day.
RESULTS
Rats were monitored for survival rate and daily activity, including hair loss, sensitivity, and anorexia. We found that survival rate and oral intake were significantly increased and histologic changes were significantly decreased in the rhEGF-treated rats. There was no difference, however, between rats treated with 50 microg/mL or 100 microg/mL rhEGF.
CONCLUSION
These findings suggest that orally administered rhEGF decreased radiation-induced oral mucositis in rats.
目的
我们在大鼠模型中测试了口服重组人表皮生长因子（rhEGF）对放射性口腔黏膜炎的疗效。
方法与材料
35只7至8周龄、体重178±5克的Sprague-Dawley大鼠，使用4兆伏治疗性直线加速器以2戈瑞/分钟的速度在头部区域单次照射25戈瑞。将受照射的大鼠随机分为四组：未接受治疗的大鼠（第1组）、每天仅用赋形剂治疗三次的大鼠（第2组），以及每天用50微克/毫升（第3组）或100微克/毫升（第4组）rhEGF治疗三次的大鼠。
结果
监测大鼠的存活率和日常活动，包括脱发、敏感性和厌食情况。我们发现，rhEGF治疗的大鼠存活率和经口摄入量显著增加，组织学变化显著减少。然而，用50微克/毫升或100微克/毫升rhEGF治疗的大鼠之间没有差异。
结论
这些发现表明，口服rhEGF可减轻大鼠放射性口腔黏膜炎。
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