Bluestone Center for Clinical Research, New York University, College of Dentistry, NY, USA Department of Oral and Maxillofacial Surgery, New York University, College of Dentistry, NY, USA.
Bluestone Center for Clinical Research, New York University, College of Dentistry, NY, USA Department of Periodontics, New York University, College of Dentistry, NY, USA.
J Dent Res. 2014 Sep;93(9):868-75. doi: 10.1177/0022034514540174. Epub 2014 Jun 18.
Oral mucositis is a significant problem in cancer patients treated with radiation or chemotherapy, often hindering definitive cancer treatment. For patients with oral mucositis, pain is the most distressing symptom, leading to loss of orofacial function and poor quality of life. While oral mucositis has been well-described, its pathophysiology is poorly understood. Oral health professionals treating patients with mucositis have almost no effective therapies to treat or prevent oral mucositis. The purpose of this review is to (1) describe the current preclinical models of oral mucositis and their contribution to the understanding of mucositis pathophysiology, (2) explore preclinical studies on therapies targeting mucositis and discuss the clinical trials that have resulted from these preclinical studies, and (3) describe the proposed pathophysiology of oral mucositis pain and preclinical modeling of oral mucositis pain.
口腔黏膜炎是癌症患者在接受放疗或化疗时的一个严重问题，常导致癌症治疗无法完成。对于口腔黏膜炎患者，疼痛是最令人痛苦的症状，导致口腔功能丧失和生活质量下降。尽管口腔黏膜炎已得到很好的描述，但对其病理生理学的认识仍不清楚。治疗黏膜炎患者的口腔卫生专业人员几乎没有有效的治疗方法来治疗或预防口腔黏膜炎。本综述的目的是：(1) 描述目前口腔黏膜炎的临床前模型及其对黏膜炎病理生理学的理解的贡献；(2) 探讨针对黏膜炎的临床前研究，并讨论由此产生的临床试验；(3) 描述口腔黏膜炎疼痛的病理生理学和口腔黏膜炎疼痛的临床前建模。
