Hu抗体和Yo抗体具有异质性亲和力。

Hu and Yo antibodies have heterogeneous avidity.

作者信息

Totland Cecilie, Aarseth Jan, Vedeler Christian

机构信息

Department of Neurology, Haukeland University Hospital, Norway; Department of Clinical Medicine, University of Bergen, Norway.

出版信息

J Neuroimmunol. 2007 Apr;185(1-2):162-7. doi: 10.1016/j.jneuroim.2007.01.016. Epub 2007 Mar 2.

DOI:10.1016/j.jneuroim.2007.01.016

PMID:17336396

Abstract

Onconeural antibodies such as anti-Hu and anti-Yo may be important in the pathogenesis of paraneoplastic neurological syndromes. The avidity of these antibodies is not known. In this study, we compared the avidity of Hu and Yo antibodies both at single time points and over a time range of 2 months to 6 years. The avidity of Yo and Hu antibodies differed among the patients, but anti-Yo generally had higher avidity than anti-Hu. Whether Yo antibodies are more pathogenic than Hu antibodies are presently unknown.

摘要

诸如抗Hu和抗Yo等肿瘤神经抗体可能在副肿瘤性神经综合征的发病机制中起重要作用。这些抗体的亲和力尚不清楚。在本研究中，我们在单个时间点以及2个月至6年的时间范围内比较了Hu和Yo抗体的亲和力。Yo和Hu抗体的亲和力在患者之间有所不同，但抗Yo通常比抗Hu具有更高的亲和力。目前尚不清楚Yo抗体是否比Hu抗体更具致病性。