Acosta-Rodríguez Eva V, Merino Maria C, Montes Carolina L, Motrán C Cristina, Gruppi Adriana
Department of Clinical Biochemistry, School of Chemical Sciences, National University of Córdoba, Córdoba, Argentina.
Cytokine Growth Factor Rev. 2007 Feb-Apr;18(1-2):73-83. doi: 10.1016/j.cytogfr.2007.01.007. Epub 2007 Mar 2.
The whole life of a B-cell from a stem cell to a mature plasma cell is governed, among other factors, by cytokines and growth factors in their microenvironment. Remarkable progress in the understanding of the mechanisms of cytokines action on the B-cell compartment was achieved by analysis of gene-targeted mice. The generation of mice deficient for individual cytokines or their receptors has shed light on the in vivo function of cytokines in B-cell responses. This review focuses on the role of cytokines in the development, maturation and differentiation of different B-cell subsets into antibody-secreting cells or memory B-cells.
从干细胞到成熟浆细胞的B细胞的整个生命周期，除其他因素外，还受其微环境中的细胞因子和生长因子的调控。通过对基因靶向小鼠的分析，在理解细胞因子作用于B细胞区室的机制方面取得了显著进展。缺乏个别细胞因子或其受体的小鼠的产生，为细胞因子在B细胞反应中的体内功能提供了线索。本综述重点关注细胞因子在不同B细胞亚群发育、成熟以及分化为抗体分泌细胞或记忆B细胞过程中的作用。
