Gurbuxani Sandeep, Anastasi John
Section of Hematopathology, Department of Pathology, University of Chicago, Chicago, Illinois, USA.
Clin Gastroenterol Hepatol. 2007 Apr;5(4):417-21. doi: 10.1016/j.cgh.2006.11.026. Epub 2007 Mar 2.
Although primary gastrointestinal (GI) lymphomas are an infrequent occurrence and represent 1%-4% of the malignant tumors of the GI tract, secondary involvement of the GI tract by lymphoma is not uncommon. Several controversies remain about the prognostic stratification and the optimal treatment modalities for these lymphomas. A crucial component of answering these questions is an accurate and complete characterization of the tumor. The currently used World Health Organization classification of hematologic malignancies requires integration of morphologic, immunophenotypic, and genotypic features to define a disease type. Through the use of a representative case we highlight how this information is used for the appropriate diagnosis of a GI lymphoma. We also discuss the clinical features, including radiologic and endoscopic findings in patients presenting with a GI lymphoma. The review is a pathologist's perspective on what to do when suspecting a lymphoma of the GI tract.
尽管原发性胃肠道淋巴瘤并不常见，仅占胃肠道恶性肿瘤的1%-4%，但淋巴瘤继发累及胃肠道却并不罕见。关于这些淋巴瘤的预后分层和最佳治疗方式仍存在一些争议。回答这些问题的一个关键因素是对肿瘤进行准确而全面的特征描述。目前使用的世界卫生组织血液系统恶性肿瘤分类需要整合形态学、免疫表型和基因型特征来定义疾病类型。通过一个典型病例，我们强调如何利用这些信息对胃肠道淋巴瘤进行恰当诊断。我们还讨论了临床特征，包括胃肠道淋巴瘤患者的影像学和内镜检查结果。这篇综述是从病理学家的角度阐述怀疑胃肠道淋巴瘤时应如何处理。
