基于亲和力从混合物中筛选二肽基肽酶-4（DPP-4）配体的排序方法
Affinity-based ranking of ligands for DPP-4 from mixtures.
作者信息
Adam Gregory C, Meng Juncai, Athanasopoulos John, Zhang Xiaoping, Chapman Kevin T
机构信息
Department of Target Validation, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA.
出版信息
Bioorg Med Chem Lett. 2007 May 1;17(9):2404-7. doi: 10.1016/j.bmcl.2007.02.040. Epub 2007 Feb 17.
Affinity-based selection strategies have recently emerged as a complement to traditional high throughput screening for the rapid discovery of lead compounds for the large number of protein targets emerging from--omics technologies. Herein, we describe a method for the ranking of mixtures of ligands by affinity selection and apply it to rank order a set of inhibitors for the enzyme dipeptidyl peptidase IV.
基于亲和力的筛选策略最近已成为传统高通量筛选的补充手段，用于从组学技术产生的大量蛋白质靶点中快速发现先导化合物。在此，我们描述了一种通过亲和力筛选对配体混合物进行排序的方法，并将其应用于对一组二肽基肽酶IV抑制剂进行排序。
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