Javaid Aisha, Hasan Ruqaiya, Zaib Asma, Mansoor Shama
Department of Physiology, University of Karachi, Karachi-75270, Pakistan.
Pak J Pharm Sci. 2007 Jan;20(1):67-71.
30 patients comprised of 3 equal groups which were given 3 types of treatment. Group I given metformin HCl (1+1), maintained a sugar level of 129-340 mg/100 ml. Group II given glibenclamide(1+1), maintained a sugar level of 120-325 mg/100 ml. Group III given a combination of both drugs, maintained a sugar level 112 mg - 46 mg/100 ml. The most suitable of the 3 was the last treatment. Serum electrolytes were measured in all the three groups. Patients taking metformin HCl and glibenclamide showed non significant low sodium with high potassium values respectively. When used in combination, they maintained normal values. On the other hand, serum calcium levels were significantly high in patients taking metformin HCl only; when compared with glibenclamide. However, when both drugs were given to patients, serum calcium remained at normal levels.
30名患者被分为3个相等的组，分别接受3种治疗。第一组给予盐酸二甲双胍（1 + 1），血糖水平维持在129 - 340毫克/100毫升。第二组给予格列本脲（1 + 1），血糖水平维持在120 - 325毫克/100毫升。第三组给予两种药物的组合，血糖水平维持在112毫克 - 46毫克/100毫升。这三种治疗中最合适的是最后一种治疗。对所有三组患者均进行了血清电解质测量。服用盐酸二甲双胍和格列本脲的患者分别显示出钠水平无显著降低和钾水平升高。当联合使用时，它们维持正常水平。另一方面，仅服用盐酸二甲双胍的患者血清钙水平显著升高；与格列本脲相比。然而，当两种药物都给予患者时，血清钙保持在正常水平。
