含一氧化氮合酶的诺卡氏菌属菌株NRRL 5646中的硫醇
Thiols in nitric oxide synthase-containing Nocardia sp. strain NRRL 5646.
作者信息
Lee Sungwon, Bergeron Hélène, Lau Peter C K, Rosazza John P N
机构信息
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Center for Biocatalysis and Bioprocessing, The University of Iowa, Iowa City, IA 52242, USA.
出版信息
Appl Environ Microbiol. 2007 May;73(9):3095-7. doi: 10.1128/AEM.02809-06. Epub 2007 Mar 2.
Abstract
Mycothiol (MSH) [1-D-myo-inosityl-2-(N-acetyl-l-cysteinyl)amido-2-deoxy-alpha-D-glucopyranoside], isolated as the bimane derivative, was established to be the major thiol in Nocardia sp. strain NRRL 5646, a species most closely related to Nocardia brasiliensis strain DSM 43758(T). Thiol formation and detection of MSH-dependent formaldehyde dehydrogenase activity in cell extracts are relevant to the possible modulation of nitric oxide toxicity generated by strain NRRL 5646.
摘要
作为双硫腙衍生物分离得到的麦角硫因（MSH）[1-D-肌醇-2-(N-乙酰基-L-半胱氨酰)氨基-2-脱氧-α-D-吡喃葡萄糖苷]，被确定为诺卡氏菌属菌株NRRL 5646中的主要硫醇，该菌株与巴西诺卡氏菌DSM 43758(T)菌株关系最为密切。细胞提取物中硫醇的形成以及依赖麦角硫因的甲醛脱氢酶活性的检测，与NRRL 5646菌株产生的一氧化氮毒性的可能调节有关。
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