Tin W, Gupta S
Directorate of Neonatal Medicine, The James Cook University Hospital, Middlesbrough, Cleveland, UK.
Arch Dis Child Fetal Neonatal Ed. 2007 Mar;92(2):F143-7. doi: 10.1136/adc.2005.092726.
Oxygen is the most commonly used therapy in neonatal nurseries as an integral part of respiratory support. The goal of oxygen therapy is to achieve adequate delivery of oxygen to the tissue without creating oxygen toxicity. Oxygen must have been given to newborn preterm babies more than any other medicinal product in the past 60 years. Despite this, we still know very little about how much oxygen these babies actually need, or how much oxygen is safe to give, especially in the first few weeks of life. Recent observational studies have raised concerns that giving oxygen to target the saturation at "physiological" levels in newborn preterm babies may do more harm than good, but to date, clinicians have not been able to resolve the uncertainties surrounding optimum oxygen therapy.
氧气是新生儿重症监护室中最常用的治疗手段，是呼吸支持不可或缺的一部分。氧疗的目标是在不产生氧中毒的情况下，实现向组织充分输送氧气。在过去60年里，给早产新生儿使用氧气的频率超过了任何其他药品。尽管如此，我们对这些婴儿实际需要多少氧气，或者给予多少氧气是安全的，尤其是在生命的最初几周，仍然知之甚少。最近的观察性研究引发了人们的担忧，即给早产新生儿提供氧气以将血氧饱和度维持在“生理”水平可能弊大于利，但迄今为止，临床医生仍无法解决围绕最佳氧疗的不确定性问题。
