Mohamed Tarek, Abdul-Hafez Amal, Gewolb Ira H, Uhal Bruce D
Department of Pediatrics and Human Development, Michigan State University, USA.
Department of Physiology, Michigan State University, USA.
J Lung Pulm Respir Res. 2020;7(1):4-13. Epub 2020 Jan 29.
Premature birth results in an increased risk of respiratory distress and often requires oxygen therapy. While the supplemental oxygen has been implicated as a cause of bronchopulmonary dysplasia (BPD), in clinical practice this supplementation usually only occurs after the patient's oxygen saturation levels have dropped. The effect of hyperoxia on neonates has been extensively studied. However, there is an unanswered fundamental question: which has the most impact-hyperoxia, hypoxia or fluctuating oxygen levels? In this review, we will summarize the reported effect of hypoxia, hyperoxia or a fluctuation of oxygen levels (hypoxia/hyperoxia cycling) in preterm neonates, with special emphasis on the lungs.
早产会增加呼吸窘迫的风险，通常需要进行氧疗。虽然补充氧气被认为是支气管肺发育不良（BPD）的一个原因，但在临床实践中，这种补充通常只在患者血氧饱和度水平下降后才会进行。高氧对新生儿的影响已得到广泛研究。然而，有一个尚未得到解答的基本问题：高氧、低氧或波动的氧水平，哪一个影响最大？在这篇综述中，我们将总结低氧、高氧或氧水平波动（低氧/高氧循环）对早产儿的影响，特别关注肺部。
