Finn Olivera J
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Immunol Res. 2006;36(1-3):73-82. doi: 10.1385/IR:36:1:73.
Cancer is a serious health problem as well as a scientific challenge. A lot has been learned about the process of transformation of a normal cell into a tumor cell by studying genes and proteins that regulate this process either in cis or in trans. However, whether these molecular mechanisms succeed in fulfilling their potential to give a clinically evident disease depends in great measure on the host response to those molecular changes. The work of my laboratory aims to provide evidence in animal models as well as in cancer patients that immune system can control cancer growth and that this important function can be improved through vaccination with well-defined tumor antigens.
癌症既是一个严重的健康问题，也是一项科学挑战。通过研究顺式或反式调节这一过程的基因和蛋白质，我们对正常细胞转变为肿瘤细胞的过程已经有了很多了解。然而，这些分子机制是否能够成功发挥其潜力，导致临床上明显的疾病，在很大程度上取决于宿主对这些分子变化的反应。我实验室的工作旨在在动物模型以及癌症患者中提供证据，证明免疫系统可以控制癌症生长，并且通过用明确的肿瘤抗原进行疫苗接种可以改善这一重要功能。
