Vallejo Abbe N
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Immunol Res. 2006;36(1-3):221-8. doi: 10.1385/IR:36:1:221.
The aging immune system is characterized by the contraction of T cell receptor (TCR) diversity and the de novo expression of NKrelated receptors (NKR) on oligoclonal T cells. NKR+ T cells likely represent a secondary immune diversification as a biological adaptation of aging to ensure host defense despite shrinkage of the TCR repertoire. NKRs are expressed in various combinations even among TCR-identical cells, and are capable of triggering effector pathways in either TCR-independent or TCR-dependent fashion. Understanding the biology of NKR+ T cells will be pivotal to the development of strategies to enhance immunity in the elderly.
衰老的免疫系统的特征是T细胞受体（TCR）多样性的收缩以及寡克隆T细胞上自然杀伤相关受体（NKR）的从头表达。NKR+ T细胞可能代表一种继发性免疫多样化，作为衰老的一种生物学适应，以确保尽管TCR库缩小但宿主仍能防御。即使在TCR相同的细胞之间，NKR也以各种组合表达，并且能够以TCR非依赖性或TCR依赖性方式触发效应途径。了解NKR+ T细胞的生物学特性对于制定增强老年人免疫力的策略至关重要。
