体内平衡与CD4 T细胞的年龄相关缺陷
Homeostasis and the age-associated defect of CD4 T cells.
作者信息
Swain Susan, Clise-Dwyer Karen, Haynes Laura
机构信息
Trudeau Institute, 154 Algonquin Ave., Saranac Lake, NY 12983, USA.
出版信息
Semin Immunol. 2005 Oct;17(5):370-7. doi: 10.1016/j.smim.2005.05.007.
Abstract
Survival and homeostatic division of naive CD4 T cells is regulated by the cellular and non-cellular milieu and together these processes ensure that a population of naive CD4 T cells persists into old age. However, the naive CD4 T cells from aged animals show reduced IL-2 production, proliferation, helper function and effector generation and memory function. We explore here whether the age-related defects in naive CD4 T cells are due to the aged environment from which they come or to intrinsic defects that are caused by homeostasis and their long lifespan.
摘要
初始CD4 T细胞的存活和稳态分裂受细胞和非细胞环境调节，这些过程共同确保初始CD4 T细胞群体持续存在至老年。然而，老年动物的初始CD4 T细胞表现出白细胞介素-2产生减少、增殖能力下降、辅助功能及效应细胞生成和记忆功能受损。我们在此探讨初始CD4 T细胞中与年龄相关的缺陷是由于其所处的衰老环境，还是由于稳态及它们较长的寿命所导致的内在缺陷。
相似文献
1
Homeostasis and the age-associated defect of CD4 T cells.体内平衡与CD4 T细胞的年龄相关缺陷
Semin Immunol. 2005 Oct;17(5):370-7. doi: 10.1016/j.smim.2005.05.007.
2
Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo.炎症细胞因子克服了体内CD4 T细胞反应中与年龄相关的缺陷。
J Immunol. 2004 May 1;172(9):5194-9. doi: 10.4049/jimmunol.172.9.5194.
3
Cell generation dynamics underlying naive T-cell homeostasis in adult humans.成人人类初始 T 细胞体内平衡的细胞生成动力学。
PLoS Biol. 2019 Oct 29;17(10):e3000383. doi: 10.1371/journal.pbio.3000383. eCollection 2019 Oct.
4
Homeostasis of naive and memory CD4+ T cells: IL-2 and IL-7 differentially regulate the balance between proliferation and Fas-mediated apoptosis.初始和记忆性CD4+ T细胞的稳态：白细胞介素-2和白细胞介素-7对增殖与Fas介导的细胞凋亡之间的平衡具有不同调节作用。
J Immunol. 2003 Jul 1;171(1):61-8. doi: 10.4049/jimmunol.171.1.61.
5
Homeostatic proliferation of naive CD4+ T cells in mesenteric lymph nodes generates gut-tropic Th17 cells.固有 CD4+T 细胞在肠系膜淋巴结中的稳态增殖产生了肠道趋向性 Th17 细胞。
J Immunol. 2013 Jun 1;190(11):5788-98. doi: 10.4049/jimmunol.1203111. Epub 2013 Apr 22.
6
Impact of post-thymic cellular longevity on the development of age-associated CD4+ T cell defects.胸腺后细胞寿命对年龄相关CD4 + T细胞缺陷发展的影响。
J Immunol. 2008 Apr 1;180(7):4465-75. doi: 10.4049/jimmunol.180.7.4465.
7
Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age.外周选择而非胸腺萎缩解释了幼稚 CD4 T 细胞多样性随年龄突然收缩的原因。
Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21432-7. doi: 10.1073/pnas.1209283110. Epub 2012 Dec 10.
8
Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.人 CD4 幼稚 T 细胞中通过表达功能性高亲和力 IL-2 受体实现的胸腺后扩增。
J Immunol. 2013 Mar 15;190(6):2554-66. doi: 10.4049/jimmunol.1202914. Epub 2013 Feb 15.
9
Survival and homeostatic proliferation of naive peripheral CD4+ T cells in the absence of self peptide:MHC complexes.在缺乏自身肽：MHC复合物的情况下，初始外周CD4 + T细胞的存活和稳态增殖。
J Immunol. 2000 Sep 1;165(5):2458-64. doi: 10.4049/jimmunol.165.5.2458.
10
Memory T-cell predominance following T-cell depletional therapy derives from homeostatic expansion of naive T cells.T细胞清除疗法后记忆性T细胞占优势源于初始T细胞的稳态扩增。
Am J Transplant. 2009 Nov;9(11):2615-23. doi: 10.1111/j.1600-6143.2009.02820.x. Epub 2009 Sep 22.
引用本文的文献
1
Benefit delayed immunosenescence by regulating CD4T cells: A promising therapeutic target for aging-related diseases.通过调节 CD4T 细胞来延缓免疫衰老：一种有前途的与衰老相关疾病的治疗靶点。
Aging Cell. 2024 Oct;23(10):e14317. doi: 10.1111/acel.14317. Epub 2024 Aug 18.
2
Interconnections between Inflammageing and Immunosenescence during Ageing.衰老过程中炎症与免疫衰老的相互关系。
Cells. 2022 Jan 21;11(3):359. doi: 10.3390/cells11030359.
3
The Impact of Ageing on the CNS Immune Response in Alzheimer's Disease.衰老对阿尔茨海默病中枢神经系统免疫反应的影响。
Front Immunol. 2021 Sep 17;12:738511. doi: 10.3389/fimmu.2021.738511. eCollection 2021.
4
Hybrid computational modeling demonstrates the utility of simulating complex cellular networks in type 1 diabetes.混合计算模型证明了模拟 1 型糖尿病中复杂细胞网络的实用性。
PLoS Comput Biol. 2021 Sep 27;17(9):e1009413. doi: 10.1371/journal.pcbi.1009413. eCollection 2021 Sep.
5
Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress.慢性使用对乙酰氨基酚通过靶向炎症和氧化应激来保护肝脏免于衰老。
Aging (Albany NY). 2021 Mar 29;13(6):7800-7827. doi: 10.18632/aging.202884.
6
Effects of zinc status on age-related T cell dysfunction and chronic inflammation.锌营养状况对与年龄相关的 T 细胞功能障碍和慢性炎症的影响。
Biometals. 2021 Apr;34(2):291-301. doi: 10.1007/s10534-020-00279-5. Epub 2021 Jan 3.
7
Memory CD4 T Cells in Immunity and Autoimmune Diseases.记忆性 CD4 T 细胞在免疫和自身免疫性疾病中的作用。
Cells. 2020 Feb 25;9(3):531. doi: 10.3390/cells9030531.
8
Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging.年龄相关性胸腺退化对免疫衰老和炎症衰老的影响
Immun Ageing. 2020 Jan 20;17:2. doi: 10.1186/s12979-020-0173-8. eCollection 2020.
9
Bench-to-bedside strategies for osteoporotic fracture: From osteoimmunology to mechanosensation.骨质疏松性骨折的从实验室到临床策略：从骨免疫学至机械感觉
Bone Res. 2019 Aug 15;7:25. doi: 10.1038/s41413-019-0066-7. eCollection 2019.
10
Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18.衰老小鼠效应性 CD8 T 细胞的转录编程缺陷是细胞外在的，并可通过施用 IL-12 和 IL-18 进行纠正。
Front Immunol. 2019 Sep 18;10:2206. doi: 10.3389/fimmu.2019.02206. eCollection 2019.
本文引用的文献
1
The effect of age on the cognate function of CD4+ T cells.年龄对CD4+ T细胞同源功能的影响。
Immunol Rev. 2005 Jun;205:220-8. doi: 10.1111/j.0105-2896.2005.00255.x.
2
Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen.老年动物中新生成的CD4 T细胞在对抗抗原时不会表现出与年龄相关的缺陷。
J Exp Med. 2005 Mar 21;201(6):845-51. doi: 10.1084/jem.20041933.
3
Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses.CD4 T细胞同源辅助功能中与年龄相关的缺陷会导致体液免疫反应减弱。
J Exp Med. 2004 Dec 20;200(12):1613-22. doi: 10.1084/jem.20041395.
4
CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection.急性感染后，CD4+ T细胞对于记忆性CD8+ T细胞的维持而非编程是必需的。
Nat Immunol. 2004 Sep;5(9):927-33. doi: 10.1038/ni1105. Epub 2004 Aug 8.
5
Is immunosenescence infectious?免疫衰老具有传染性吗？
Trends Immunol. 2004 Aug;25(8):406-10. doi: 10.1016/j.it.2004.05.006.
6
Age-associated change in the frequency of memory CD4+ T cells impairs long term CD4+ T cell responses to influenza vaccine.记忆性CD4+ T细胞频率的年龄相关性变化会损害CD4+ T细胞对流感疫苗的长期应答。
J Immunol. 2004 Jul 1;173(1):673-81. doi: 10.4049/jimmunol.173.1.673.
7
CD4 T cell responses to influenza infection.CD4 T细胞对流感感染的反应。
Semin Immunol. 2004 Jun;16(3):171-7. doi: 10.1016/j.smim.2004.02.004.
8
Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo.炎症细胞因子克服了体内CD4 T细胞反应中与年龄相关的缺陷。
J Immunol. 2004 May 1;172(9):5194-9. doi: 10.4049/jimmunol.172.9.5194.
9
Immunity to tuberculosis.对结核病的免疫力。
Annu Rev Immunol. 2004;22:599-623. doi: 10.1146/annurev.immunol.22.012703.104635.
10
Textbook germinal centers?典型的生发中心？
J Immunol. 2004 Mar 15;172(6):3369-75. doi: 10.4049/jimmunol.172.6.3369.
Zotero 插件