诺里病基因定位于Xp上的DXS7和DXS426之间。
Localisation of the gene for Norrie disease to between DXS7 and DXS426 on Xp.
作者信息
Lindsay S, Thiselton D L, Bateman J B, Ngo J T, Sparkes R S, Coleman M, Davies K E, Bhattacharya S S
机构信息
Molecular Genetics Unit, University of Newcastle-upon-Tyne, UK.
出版信息
Hum Genet. 1992 Jan;88(3):349-50. doi: 10.1007/BF00197273.
A highly informative microsatellite marker, DXS426, which maps proximal to DXS7 in the interval Xp11.4-Xp11.23, has been used to refine further the localisation of the gene for Norrie disease (NDP). The results from a multiply informative crossover localize the NDP gene proximal to DXS7. In conjunction with information from 2 NDP patients who have a deletion for DXS7 but not for DSX426, our data indicate that the NDP gene lies between DXS7 and DXS426 on proximal Xp.
一个信息丰富的微卫星标记DXS426，定位于Xp11.4 - Xp11.23区间内DXS7近端，已被用于进一步精确诺里病（NDP）基因的定位。一个多重信息交换的结果将NDP基因定位于DXS7近端。结合两名NDP患者的信息，他们有DXS7缺失但没有DXS426缺失，我们的数据表明NDP基因位于近端Xp上的DXS7和DXS426之间。
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