Wheaton Michael, Timpano Kiara R, Lasalle-Ricci V Holland, Murphy Dennis
Laboratory of Clinical Science, National Institute of Mental Health, USA.
J Anxiety Disord. 2008;22(2):243-52. doi: 10.1016/j.janxdis.2007.01.015. Epub 2007 Feb 12.
Hoarding frequently occurs in obsessive-compulsive disorder (OCD), and some evidence suggests that it constitutes a distinct OCD subtype, with genetic contributions. This study investigated differences between OCD patients with and without hoarding symptoms. Of the 473 OCD patients studied, 24% were classified as hoarders according to combined interviewer and self-ratings, which were validated with the Savings Inventory-Revised in a subsample. Hoarders suffered from significantly more severe OCD symptoms, (especially compulsions) and had greater impairment and dysphoria. Hoarders also had more comorbid psychiatric disorders. Further study revealed that many of these differences were attributable to the female subjects: Compared to female non-hoarders, female hoarders were more likely to suffer from bipolar I, substance abuse, panic disorder, binge-eating disorder, and had greater OCD severity. Male hoarders had an increased prevalence of social phobia compared to non-hoarding males. These results suggest that there are gender-specific differences in the hoarding sub-phenotype of OCD.
囤积行为在强迫症（OCD）中经常出现，一些证据表明它构成了一种独特的、具有遗传因素的强迫症亚型。本研究调查了有囤积症状和无囤积症状的强迫症患者之间的差异。在研究的473名强迫症患者中，根据访谈者和自我评定相结合的方式，24%被归类为囤积者，这一分类在一个子样本中通过《储蓄量表修订版》得到了验证。囤积者患有明显更严重的强迫症症状（尤其是强迫行为），且有更大的功能损害和烦躁不安。囤积者还患有更多的共病精神障碍。进一步研究发现，其中许多差异可归因于女性受试者：与女性非囤积者相比，女性囤积者更有可能患有双相I型障碍、物质滥用、惊恐障碍、暴饮暴食症，且强迫症严重程度更高。与非囤积男性相比，男性囤积者社交恐惧症的患病率更高。这些结果表明，强迫症的囤积子表型存在性别特异性差异。
