强迫症协作遗传学研究结果：强迫症家族中14号染色体上与强迫性囤积的显著连锁关系
Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study.
作者信息
Samuels Jack, Shugart Yin Yao, Grados Marco A, Willour Virginia L, Bienvenu O Joseph, Greenberg Benjamin D, Knowles James A, McCracken James T, Rauch Scott L, Murphy Dennis L, Wang Ying, Pinto Anthony, Fyer Abby J, Piacentini John, Pauls David L, Cullen Bernadette, Rasmussen Steven A, Hoehn-Saric Rudolf, Valle David, Liang Kung-Yee, Riddle Mark A, Nestadt Gerald
机构信息
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 N. Wolfe St., Meyer 4-181, Baltimore, MD 21287-7228, USA.
出版信息
Am J Psychiatry. 2007 Mar;164(3):493-9. doi: 10.1176/ajp.2007.164.3.493.
OBJECTIVE
Individuals with obsessive-compulsive disorder (OCD) who have compulsive hoarding behavior are clinically different from other OCD-affected individuals. The objective of this study was to determine whether there are chromosomal regions specifically linked to compulsive hoarding behavior in families with obsessive-compulsive disorder.
METHODS
The authors used multipoint allele-sharing methods to assess for linkage in 219 multiplex OCD families collected as part of the OCD Collaborative Genetics Study. The authors treated compulsive hoarding as the phenotype of interest and also stratified families into those with and without two or more relatives affected with compulsive hoarding.
RESULTS
Using compulsive hoarding as the phenotype, there was suggestive linkage to chromosome 14 at marker D14S588 (Kong and Cox logarithm of the odds ratio [LOD] [KAC(all)=2.9]). In families with two or more hoarding relatives, there was significant linkage of OCD to chromosome 14 at marker C14S1937 (KAC(all)=3.7), whereas in families with fewer than two hoarding relatives, there was suggestive linkage to chromosome 3 at marker D3S2398 (KAC(all)=2.9).
CONCLUSIONS
The findings suggest that a region on chromosome 14 is linked with compulsive hoarding behavior in families with OCD.
目的
患有强迫性囤积行为的强迫症（OCD）患者在临床上与其他受强迫症影响的个体有所不同。本研究的目的是确定在患有强迫症的家庭中，是否存在与强迫性囤积行为特异性相关的染色体区域。
方法
作者使用多点等位基因共享方法，对作为强迫症协作遗传学研究一部分收集的219个多重强迫症家庭进行连锁分析。作者将强迫性囤积视为感兴趣的表型，并将家庭分为有两个或更多亲属患有强迫性囤积的家庭和没有此类亲属的家庭。
结果
以强迫性囤积为表型，在标记D14S588处与14号染色体存在提示性连锁（Kong和Cox优势对数比[LOD][KAC（全部）=2.9]）。在有两个或更多囤积亲属的家庭中，在标记C14S1937处强迫症与14号染色体存在显著连锁（KAC（全部）=3.7），而在囤积亲属少于两个的家庭中，在标记D3S2398处与3号染色体存在提示性连锁（KAC（全部）=2.9）。
结论
研究结果表明，14号染色体上的一个区域与患有强迫症的家庭中的强迫性囤积行为有关。
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